UBE2E1

From Wikipedia, the free encyclopedia

Ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)

PDB rendering based on 1y6l.

Available structures: 1y6l

Identifiers

Symbol(s)

UBE2E1; UBCH6

External IDs

OMIM: 602916 MGI: 107411 HomoloGene: 84372

Gene ontology
Molecular Function:	• ubiquitin-protein ligase activity • protein binding • ligase activity
Biological Process:	• ubiquitin-dependent protein catabolic process • ubiquitin cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_003341 (mRNA)
NP_003332 (protein)

XM_975886 (mRNA)
XP_980980 (protein)

Location

Chr 3: 23.82 - 23.91 Mb

n/a

Pubmed search

[1]

[2]

Ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast), also known as UBE2E1, is a human gene.^[1]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: UBE2E1 ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast).

[edit] Further reading

Pickart CM (2002). "Mechanisms underlying ubiquitination.". Annu. Rev. Biochem. 70: 503–33. doi:10.1146/annurev.biochem.70.1.503. PMID 11395416.
Chen P, Johnson P, Sommer T, et al. (1993). "Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MAT alpha 2 repressor.". Cell 74 (2): 357–69. PMID 8393731.
Nuber U, Schwarz S, Kaiser P, et al. (1996). "Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5.". J. Biol. Chem. 271 (5): 2795–800. PMID 8576257.
Anan T, Nagata Y, Koga H, et al. (1999). "Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes.". Genes Cells 3 (11): 751–63. PMID 9990509.
Nyman TA, Matikainen S, Sareneva T, et al. (2000). "Proteome analysis reveals ubiquitin-conjugating enzymes to be a new family of interferon-alpha-regulated genes.". Eur. J. Biochem. 267 (13): 4011–9. PMID 10866800.
Lenk U, Sommer T (2001). "Ubiquitin-mediated proteolysis of a short-lived regulatory protein depends on its cellular localization.". J. Biol. Chem. 275 (50): 39403–10. doi:10.1074/jbc.M006949200. PMID 10991948.
Pringa E, Martinez-Noel G, Muller U, Harbers K (2001). "Interaction of the ring finger-related U-box motif of a nuclear dot protein with ubiquitin-conjugating enzymes.". J. Biol. Chem. 276 (22): 19617–23. doi:10.1074/jbc.M100192200. PMID 11274149.
Ito K, Adachi S, Iwakami R, et al. (2001). "N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8.". Eur. J. Biochem. 268 (9): 2725–32. PMID 11322894.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics 83 (1): 153–67. PMID 14667819.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Takeuchi T, Iwahara S, Saeki Y, et al.. "Link between the Ubiquitin Conjugation System and the ISG15 Conjugation System: ISG15 Conjugation to the UbcH6 Ubiquitin E2 Enzyme.". J. Biochem. 138 (6): 711–9. doi:10.1093/jb/mvi172. PMID 16428300.