UBE2C

From Wikipedia, the free encyclopedia

Ubiquitin-conjugating enzyme E2C

PDB rendering based on 1i7k.

Available structures: 1i7k

Identifiers

Symbol(s)

UBE2C; UBCH10; dJ447F3.2

External IDs

OMIM: 605574 MGI: 1915862 HomoloGene: 5096

Gene ontology
Molecular Function:	• ubiquitin-protein ligase activity • ligase activity
Biological Process:	• ubiquitin-dependent protein catabolic process • ubiquitin cycle • cell cycle • spindle organization and biogenesis • mitosis • cyclin catabolic process • protein ubiquitination • positive regulation of exit from mitosis • phosphoinositide-mediated signaling • cell division

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007019 (mRNA)
NP_008950 (protein)

NM_026785 (mRNA)
NP_081061 (protein)

Location

Chr 20: 43.87 - 43.88 Mb

Chr 2: 164.46 - 164.47 Mb

Pubmed search

[1]

[2]

Ubiquitin-conjugating enzyme E2C, also known as UBE2C, is a human gene.^[1]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle progression. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.^[1]

[edit] References

^ ^a ^b Entrez Gene: UBE2C ubiquitin-conjugating enzyme E2C.

[edit] Further reading

Townsley FM, Aristarkhov A, Beck S, et al. (1997). "Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase.". Proc. Natl. Acad. Sci. U.S.A. 94 (6): 2362-7. PMID 9122200.
Fossey SC, Mychaleckyj JC, Pendleton JK, et al. (2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20.". Genomics 76 (1-3): 45-57. doi:10.1006/geno.2001.6584. PMID 11549316.
Tang Z, Li B, Bharadwaj R, et al. (2002). "APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex.". Mol. Biol. Cell 12 (12): 3839-51. PMID 11739784.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052.
Lin Y, Hwang WC, Basavappa R (2002). "Structural and functional analysis of the human mitotic-specific ubiquitin-conjugating enzyme, UbcH10.". J. Biol. Chem. 277 (24): 21913-21. doi:10.1074/jbc.M109398200. PMID 11927573.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Okamoto Y, Ozaki T, Miyazaki K, et al. (2003). "UbcH10 is the cancer-related E2 ubiquitin-conjugating enzyme.". Cancer Res. 63 (14): 4167-73. PMID 12874022.
Chuang TH, Ulevitch RJ (2004). "Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors.". Nat. Immunol. 5 (5): 495-502. doi:10.1038/ni1066. PMID 15107846.
Wagner KW, Sapinoso LM, El-Rifai W, et al. (2004). "Overexpression, genomic amplification and therapeutic potential of inhibiting the UbcH10 ubiquitin conjugase in human carcinomas of diverse anatomic origin.". Oncogene 23 (39): 6621-9. doi:10.1038/sj.onc.1207861. PMID 15208666.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Le XF, Lammayot A, Gold D, et al. (2005). "Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling.". J. Biol. Chem. 280 (3): 2092-104. doi:10.1074/jbc.M403080200. PMID 15504738.
Pallante P, Berlingieri MT, Troncone G, et al. (2005). "UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas.". Br. J. Cancer 93 (4): 464-71. doi:10.1038/sj.bjc.6602721. PMID 16106252.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Takahashi Y, Ishii Y, Nishida Y, et al. (2006). "Detection of aberrations of ubiquitin-conjugating enzyme E2C gene (UBE2C) in advanced colon cancer with liver metastases by DNA microarray and two-color FISH.". Cancer Genet. Cytogenet. 168 (1): 30-5. doi:10.1016/j.cancergencyto.2005.12.011. PMID 16772118.
Lin J, Raoof DA, Wang Z, et al. (2007). "Expression and effect of inhibition of the ubiquitin-conjugating enzyme E2C on esophageal adenocarcinoma.". Neoplasia 8 (12): 1062-71. doi:10.1593/neo.05832. PMID 17217624.
Ieta K, Ojima E, Tanaka F, et al. (2007). "Identification of overexpressed genes in hepatocellular carcinoma, with special reference to ubiquitin-conjugating enzyme E2C gene expression.". Int. J. Cancer 121 (1): 33-8. doi:10.1002/ijc.22605. PMID 17354233.