UBE2A

From Wikipedia, the free encyclopedia

Ubiquitin-conjugating enzyme E2A (RAD6 homolog)

PDB rendering based on 1jas.

Available structures: 1jas, 1q34, 1z3d

Identifiers

Symbol(s)

UBE2A; HHR6A; RAD6A; UBC2

External IDs

OMIM: 312180 MGI: 102959 HomoloGene: 68308

Gene ontology
Molecular Function:	• ubiquitin-protein ligase activity • ligase activity
Cellular Component:	• nucleus
Biological Process:	• postreplication repair • ubiquitin-dependent protein catabolic process • ubiquitin cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003336 (mRNA)
NP_003327 (protein)

NM_019668 (mRNA)
NP_062642 (protein)

Location

Chr X: 118.59 - 118.6 Mb

Chr X: 33.31 - 33.32 Mb

Pubmed search

[1]

[2]

Ubiquitin-conjugating enzyme E2A (RAD6 homolog), also known as UBE2A, is a human gene.^[1]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Multiple alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.^[1]

[edit] References

^ ^a ^b Entrez Gene: UBE2A ubiquitin-conjugating enzyme E2A (RAD6 homolog).

[edit] Further reading

Koken MH, Smit EM, Jaspers-Dekker I, et al. (1992). "Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31.". Genomics 12 (3): 447-53. PMID 1559696.
Koken MH, Reynolds P, Jaspers-Dekker I, et al. (1991). "Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6.". Proc. Natl. Acad. Sci. U.S.A. 88 (20): 8865-9. PMID 1717990.
Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank.". Gene 150 (2): 243-50. PMID 7821789.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Tateishi S, Sakuraba Y, Masuyama S, et al. (2000). "Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens.". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 7927-32. PMID 10884424.
Xin H, Lin W, Sumanasekera W, et al. (2000). "The human RAD18 gene product interacts with HHR6A and HHR6B.". Nucleic Acids Res. 28 (14): 2847-54. PMID 10908344.
Miura T, Klaus W, Ross A, et al. (2003). "The NMR structure of the class I human ubiquitin-conjugating enzyme 2b.". J. Biomol. NMR 22 (1): 89-92. PMID 11885984.
Shekhar MP, Lyakhovich A, Visscher DW, et al. (2002). "Rad6 overexpression induces multinucleation, centrosome amplification, abnormal mitosis, aneuploidy, and transformation.". Cancer Res. 62 (7): 2115-24. PMID 11929833.
Sarcevic B, Mawson A, Baker RT, Sutherland RL (2002). "Regulation of the ubiquitin-conjugating enzyme hHR6A by CDK-mediated phosphorylation.". EMBO J. 21 (8): 2009-18. doi:10.1093/emboj/21.8.2009. PMID 11953320.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Suzumori N, Burns KH, Yan W, Matzuk MM (2003). "RFPL4 interacts with oocyte proteins of the ubiquitin-proteasome degradation pathway.". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 550-5. doi:10.1073/pnas.0234474100. PMID 12525704.
Lyakhovich A, Shekhar MP (2003). "Supramolecular complex formation between Rad6 and proteins of the p53 pathway during DNA damage-induced response.". Mol. Cell. Biol. 23 (7): 2463-75. PMID 12640129.
Kunapuli P, Somerville R, Still IH, Cowell JK (2003). "ZNF198 protein, involved in rearrangement in myeloproliferative disease, forms complexes with the DNA repair-associated HHR6A/6B and RAD18 proteins.". Oncogene 22 (22): 3417-23. doi:10.1038/sj.onc.1206408. PMID 12776193.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Nascimento RM, Otto PA, de Brouwer AP, Vianna-Morgante AM (2006). "UBE2A, which encodes a ubiquitin-conjugating enzyme, is mutated in a novel X-linked mental retardation syndrome.". Am. J. Hum. Genet. 79 (3): 549-55. doi:10.1086/507047. PMID 16909393.