UBE1L

From Wikipedia, the free encyclopedia

Ubiquitin-activating enzyme E1-like

Identifiers

UBE1L; D8; MGC12713; UBE2

External IDs

OMIM: 191325 MGI: 1349462 HomoloGene: 2502

Gene ontology
Molecular Function:	• nucleotide binding • ubiquitin activating enzyme activity • ATP binding • enzyme activator activity • ligase activity • ISG15 activating enzyme activity
Biological Process:	• ubiquitin cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_003335 (mRNA)
NP_003326 (protein)

NM_023738 (mRNA)
NP_076227 (protein)

Location

Chr 3: 49.82 - 49.83 Mb

n/a

Pubmed search

[1]

[2]

Ubiquitin-activating enzyme E1-like, also known as UBE1L, is a human gene.^[1]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia.^[1]

[edit] References

^ ^a ^b Entrez Gene: UBE1L ubiquitin-activating enzyme E1-like.

[edit] Further reading

Carritt B, Kok K, van den Berg A, et al. (1992). "A gene from human chromosome region 3p21 with reduced expression in small cell lung cancer.". Cancer Res. 52 (6): 1536–41. PMID 1311632.
Kok K, Van den Berg A, Veldhuis PM, et al. (1995). "The genomic structure of the human UBE1L gene.". Gene Expr. 4 (3): 163–75. PMID 7734949.
Kok K, Hofstra R, Pilz A, et al. (1993). "A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme.". Proc. Natl. Acad. Sci. U.S.A. 90 (13): 6071–5. PMID 8327486.
McLaughlin PM, Helfrich W, Kok K, et al. (2000). "The ubiquitin-activating enzyme E1-like protein in lung cancer cell lines.". Int. J. Cancer 85 (6): 871–6. PMID 10709110.
Yuan W, Krug RM (2001). "Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein.". EMBO J. 20 (3): 362–71. doi:10.1093/emboj/20.3.362. PMID 11157743.
Kitareewan S, Pitha-Rowe I, Sekula D, et al. (2002). "UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia.". Proc. Natl. Acad. Sci. U.S.A. 99 (6): 3806–11. doi:10.1073/pnas.052011299. PMID 11891284.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Pitha-Rowe I, Hassel BA, Dmitrovsky E (2004). "Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia.". J. Biol. Chem. 279 (18): 18178–87. doi:10.1074/jbc.M309259200. PMID 14976209.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Lenschow DJ, Giannakopoulos NV, Gunn LJ, et al. (2006). "Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo.". J. Virol. 79 (22): 13974–83. doi:10.1128/JVI.79.22.13974-13983.2005. PMID 16254333.
Takeuchi T, Iwahara S, Saeki Y, et al.. "Link between the Ubiquitin Conjugation System and the ISG15 Conjugation System: ISG15 Conjugation to the UbcH6 Ubiquitin E2 Enzyme.". J. Biochem. 138 (6): 711–9. doi:10.1093/jb/mvi172. PMID 16428300.