UBE1C

From Wikipedia, the free encyclopedia

Ubiquitin-activating enzyme E1C (UBA3 homolog, yeast)

PDB rendering based on 1r4m.

Available structures: 1r4m, 1r4n, 1tt5, 1y8x, 1yov, 2nvu

Identifiers

Symbol(s)

UBE1C; DKFZp566J164; MGC22384; UBA3; hUba3

External IDs

OMIM: 603172 MGI: 1341217 HomoloGene: 2951

Gene ontology
Molecular Function:	• nucleotide binding • catalytic activity • ubiquitin activating enzyme activity • protein binding • ATP binding • ligase activity • protein heterodimerization activity
Cellular Component:	• cellular_component • nucleus
Biological Process:	• regulation of progression through cell cycle • mitotic cell cycle • proteolysis • ubiquitin cycle • endomitotic cell cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003968 (mRNA)
NP_003959 (protein)

NM_011666 (mRNA)
NP_035796 (protein)

Location

Chr 3: 69.19 - 69.21 Mb

Chr 6: 97.15 - 97.17 Mb

Pubmed search

[1]

[2]

Ubiquitin-activating enzyme E1C (UBA3 homolog, yeast), also known as UBE1C, is a human gene.^[1]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: UBE1C ubiquitin-activating enzyme E1C (UBA3 homolog, yeast).

[edit] Further reading

Osaka F, Kawasaki H, Aida N, et al. (1998). "A new NEDD8-ligating system for cullin-4A.". Genes Dev. 12 (15): 2263-8. PMID 9694792.
Gong L, Yeh ET (1999). "Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway.". J. Biol. Chem. 274 (17): 12036-42. PMID 10207026.
Gubin AN, Njoroge JM, Bouffard GG, Miller JL (1999). "Gene expression in proliferating human erythroid cells.". Genomics 59 (2): 168-77. doi:10.1006/geno.1999.5855. PMID 10409428.
Chen Y, McPhie DL, Hirschberg J, Neve RL (2000). "The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons.". J. Biol. Chem. 275 (12): 8929-35. PMID 10722740.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287-92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Walden H, Podgorski MS, Schulman BA (2003). "Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8.". Nature 422 (6929): 330-4. doi:10.1038/nature01456. PMID 12646924.
Bohnsack RN, Haas AL (2003). "Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer.". J. Biol. Chem. 278 (29): 26823-30. doi:10.1074/jbc.M303177200. PMID 12740388.
Walden H, Podgorski MS, Huang DT, et al. (2004). "The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1.". Mol. Cell 12 (6): 1427-37. PMID 14690597.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Huang DT, Miller DW, Mathew R, et al. (2004). "A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8.". Nat. Struct. Mol. Biol. 11 (10): 927-35. doi:10.1038/nsmb826. PMID 15361859.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Huang DT, Paydar A, Zhuang M, et al. (2005). "Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1.". Mol. Cell 17 (3): 341-50. doi:10.1016/j.molcel.2004.12.020. PMID 15694336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.
Hiller M, Huse K, Szafranski K, et al. (2007). "Single-nucleotide polymorphisms in NAGNAG acceptors are highly predictive for variations of alternative splicing.". Am. J. Hum. Genet. 78 (2): 291-302. doi:10.1086/500151. PMID 16400609.
Norman JA, Shiekhattar R (2006). "Analysis of Nedd8-associated polypeptides: a model for deciphering the pathway for ubiquitin-like modifications.". Biochemistry 45 (9): 3014-9. doi:10.1021/bi052435a. PMID 16503656.
Li T, Santockyte R, Shen RF, et al. (2006). "A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers.". Arch. Biochem. Biophys. 453 (1): 70-4. doi:10.1016/j.abb.2006.03.002. PMID 16620772.