UAP1

From Wikipedia, the free encyclopedia

UDP-N-acteylglucosamine pyrophosphorylase 1

PDB rendering based on 1jv1.

Available structures: 1jv1, 1jv3, 1jvd, 1jvg, 1vm8

Identifiers

Symbol(s)

UAP1; AGX1; AgX; SPAG2

External IDs

OMIM: 602862 MGI: 1334459 HomoloGene: 2342

Gene ontology
Molecular Function:	• UDP-N-acetylglucosamine diphosphorylase activity • transferase activity • nucleotidyltransferase activity
Biological Process:	• UDP-N-acetylglucosamine biosynthetic process • metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_003115 (mRNA)
NP_003106 (protein)

XM_992717 (mRNA)
XP_997811 (protein)

Location

Chr 1: 160.8 - 160.84 Mb

n/a

Pubmed search

[1]

[2]

UDP-N-acteylglucosamine pyrophosphorylase 1, also known as UAP1, is a human gene.^[1]

[edit] References

^ Entrez Gene: UAP1 UDP-N-acteylglucosamine pyrophosphorylase 1.

[edit] Further reading

Diekman AB, Goldberg E (1994). "Characterization of a human antigen with sera from infertile patients.". Biol. Reprod. 50 (5): 1087-93. PMID 8025165.
Mio T, Yabe T, Arisawa M, Yamada-Okabe H (1998). "The eukaryotic UDP-N-acetylglucosamine pyrophosphorylases. Gene cloning, protein expression, and catalytic mechanism.". J. Biol. Chem. 273 (23): 14392-7. PMID 9603950.
Diekman AB, Olson G, Goldberg E (1998). "Expression of the human antigen SPAG2 in the testis and localization to the outer dense fibers in spermatozoa.". Mol. Reprod. Dev. 50 (3): 284-93. doi:10.1002/(SICI)1098-2795(199807)50:3<284::AID-MRD4>3.0.CO;2-F. PMID 9621304.
Wang-Gillam A, Pastuszak I, Elbein AD (1998). "A 17-amino acid insert changes UDP-N-acetylhexosamine pyrophosphorylase specificity from UDP-GalNAc to UDP-GlcNAc.". J. Biol. Chem. 273 (42): 27055-7. PMID 9765219.
Peneff C, Ferrari P, Charrier V, et al. (2002). "Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture.". EMBO J. 20 (22): 6191-202. doi:10.1093/emboj/20.22.6191. PMID 11707391.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315-21. doi:10.1038/nature04727. PMID 16710414.