UACA

From Wikipedia, the free encyclopedia

Uveal autoantigen with coiled-coil domains and ankyrin repeats

Identifiers

UACA; FLJ10128; KIAA1561; MGC141967; MGC141969; NUCLING

External IDs

MGI: 1919815 HomoloGene: 74297

Gene ontology
Molecular Function:	• molecular_function • protein binding
Cellular Component:	• extracellular region • membrane fraction • soluble fraction • nucleus • nuclear envelope • cytoplasm • cytosol • cytoskeleton • apoptosome • perinuclear region of cytoplasm
Biological Process:	• DNA damage response, signal transduction resulting in induction of apoptosis • induction of apoptosis by oxidative stress • response to UV • viral reproduction • positive regulation of protein import into nucleus • negative regulation of NF-kappaB import into nucleus • positive regulation of apoptosis • positive regulation of caspase activity • negative regulation of inflammatory response

Orthologs

Human

Mouse

Refseq

NM_001008224 (mRNA)
NP_001008225 (protein)

NM_028283 (mRNA)
NP_082559 (protein)

Location

Chr 15: 68.73 - 68.84 Mb

Chr 9: 60.59 - 60.68 Mb

Pubmed search

[1]

[2]

Uveal autoantigen with coiled-coil domains and ankyrin repeats, also known as UACA, is a human gene.^[1]

[edit] References

^ Entrez Gene: UACA uveal autoantigen with coiled-coil domains and ankyrin repeats.

[edit] Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (4): 273-81. PMID 10997877.
Yamada K, Senju S, Nakatsura T, et al. (2001). "Identification of a novel autoantigen UACA in patients with panuveitis.". Biochem. Biophys. Res. Commun. 280 (4): 1169-76. doi:10.1006/bbrc.2001.4189. PMID 11162650.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773-84. doi:10.1101/gr.406902. PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97-105. doi:10.1038/ncb1086. PMID 14743216.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707-16. doi:10.1038/nbt971. PMID 15146197.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Ohkura T, Taniguchi S, Yamada K, et al. (2004). "Detection of the novel autoantibody (anti-UACA antibody) in patients with Graves' disease.". Biochem. Biophys. Res. Commun. 321 (2): 432-40. doi:10.1016/j.bbrc.2004.06.162. PMID 15358194.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.