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| U98 small nucleolar RNA |
 |
| Type: |
Gene; snRNA; guide; HACA-box; |
| 2° structure: |
Predicted; PFOLD; |
| Seed alignment: |
PubMed |
| Avg length: |
133.3 nucleotides |
| Avg identity: |
78% |
|
U98 small nucleolar RNA also is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifiying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide' RNA.
U98 belongs to the H/ACA box class of snoRNAs which are thought to guide the sites of modification of uridines to pseudouridines, the target for this family is unknown [1][2]. The mouse homolog was cloned and is called MBII-367[3].
[edit] References
- ^ Vitali P, Royo H, Seitz H, Bachellerie JP, Hüttenhofer A, Cavaillé J (2003). "Identification of 13 novel human modification guide RNAs". Nucleic Acids Res. 31 (22): 6543–51. PMID 14602913.
- ^ Ganot P, Caizergues-Ferrer M, Kiss T (1997). "The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA accumulation". Genes Dev. 11 (7): 941–56. PMID 9106664.
- ^ Hüttenhofer A, Kiefmann M, Meier-Ewert S, et al (2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". EMBO J. 20 (11): 2943–53. doi:10.1093/emboj/20.11.2943. PMID 11387227.
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