U5 spliceosomal RNA

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U5 spliceosomal RNA

Type:	Gene; snRNA; splicing;
2° structure:	Published; PubMed; Griffiths-Jones SR
Seed alignment:	Zwieb C, The uRNA database, PubMed
Avg length:	117.7 nucleotides
Avg identity:	61%

U5 RNA is a non-coding RNA that is a component of both types of known spliceosome. The precise function of this molecule is unknown, though it is known that the 5' loop is required for splice site selection and p220 binding, and that both the 3' stem-loop and the Sm site are important for Sm protein binding and cap methylation.

[edit] References

[1] Zwieb, C (1997). "The uRNA database". Nucleic Acids Res 25: 102–103. doi:10.1093/nar/25.1.102. PMID 9016512.
[2] Hinz, M; Moore MJ, Bindereif A (1996). "Domain analysis of human U5 RNA. Cap trimethylation, protein binding, and spliceosome assembly". J Biol Chem 271: 19001–19007. doi:10.1074/jbc.271.31.19001. PMID 8702566.
[3] Thomas, J; Lea K, Zucker-Aprison E, Blumenthal T (1990). "The spliceosomal snRNAs of Caenorhabditis elegans". Nucleic Acids Res 18: 2633–2642. doi:10.1093/nar/18.9.2633. PMID 2339054.