U.S. Route 378

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U.S. Route 378
Length:	234 mi[1] (377 km)
West end:	US 78/GA 10/BUS GA 10/GA 17/BUS GA 17/GA 47 at Washington, GA
Major junctions:	US 178 in Saluda, SC I-20 in Columbia, SC US 15 in Sumter, SC I-95 near Turbeville, SC US 52 in Lake City, SC
East end:	US 501/US 701 at Conway, SC
United States Numbered Highways Spur of US 78 List - Bannered - Divided - Replaced

U.S. Route 378 is a spur of U.S. Route 78. It currently runs for 234 miles (377 km) from Conway, South Carolina at U.S. Route 501 to Washington, Georgia at U.S. Route 78. It passes through the states of South Carolina and Georgia. It goes through the cities of Columbia, South Carolina and Sumter, South Carolina.

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