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| U1A polyadenylation inhibition element (PIE) |
 |
| Type: |
Cis-reg; |
| 2° structure: |
Published; PubMed |
| Seed alignment: |
PubMed |
| Avg length: |
74.0 nucleotides |
| Avg identity: |
80% |
|
The U1A polyadenylation inhibition element (PIE) is an RNA element which is responsible for the regulation of the length of the polyA tail of the U1A protein pre-mRNA. The PIE is located in the U1A mRNA 3' UTR. PIE adopts a U-shaped structure, with binding sites for a single U1A protein at each bend and when complexed with the two proteins it blocks activity of poly(A) polymerase (PAP), and inhibits its activity.[1] [2]
[edit] References
- ^ Clerte, C; Hall KB (2004). "Global and Local Dynamics of the U1A Polyadenylation Inhibition Element (PIE) RNA and PIE RNA-U1A Complexes". Biochemistry 43: 13404–13415. doi:10.1021/bi049117g. PMID 15491147.
- ^ Varani, L; Gunderson SI, Mattaj IW, Kay LE, Neuhaus D, Varani G (2000). "The NMR structure of the 38 kDa U1A protein - PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein". Nat Struct Biol 7: 329–335. doi:10.1038/74101. PMID 10742179.
[edit] External links
