Tyrosine kinase 2

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Tyrosine kinase 2
Identifiers
Symbol(s) TYK2; JTK1
External IDs OMIM: 176941 MGI: 1929470 HomoloGene: 20712
EC number 2.7.1.112
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 7297 54721
Ensembl ENSG00000105397 ENSMUSG00000032175
Uniprot P29597 Q2M4G5
Refseq NM_003331 (mRNA)
NP_003322 (protein)		 NM_018793 (mRNA)
NP_061263 (protein)
Location Chr 19: 10.32 - 10.35 Mb Chr 9: 20.85 - 20.88 Mb
Pubmed search [1] [2]

Tyrosine kinase 2, also known as TYK2, is a human gene.[1]

Tyk2 was the first member of the JAK family that was described. It has been implicated in IFN-α, IL-6, IL-10 and IL-12 signaling.

[edit] External links

[edit] References

  1. ^ Entrez Gene: TYK2 tyrosine kinase 2.

[edit] Further reading

  • Velazquez L, Fellous M, Stark GR, Pellegrini S (1992). "A protein tyrosine kinase in the interferon alpha/beta signaling pathway.". Cell 70 (2): 313–22. PMID 1386289. 
  • Krolewski JJ, Lee R, Eddy R, et al. (1990). "Identification and chromosomal mapping of new human tyrosine kinase genes.". Oncogene 5 (3): 277–82. PMID 2156206. 
  • Firmbach-Kraft I, Byers M, Shows T, et al. (1990). "tyk2, prototype of a novel class of non-receptor tyrosine kinase genes.". Oncogene 5 (9): 1329–36. PMID 2216457. 
  • Partanen J, Mäkelä TP, Alitalo R, et al. (1991). "Putative tyrosine kinases expressed in K-562 human leukemia cells.". Proc. Natl. Acad. Sci. U.S.A. 87 (22): 8913–7. PMID 2247464. 
  • Colamonici O, Yan H, Domanski P, et al. (1994). "Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase.". Mol. Cell. Biol. 14 (12): 8133–42. PMID 7526154. 
  • Novak U, Harpur AG, Paradiso L, et al. (1995). "Colony-stimulating factor 1-induced STAT1 and STAT3 activation is accompanied by phosphorylation of Tyk2 in macrophages and Tyk2 and JAK1 in fibroblasts.". Blood 86 (8): 2948–56. PMID 7579387. 
  • Domanski P, Yan H, Witte MM, et al. (1995). "Homodimerization and intermolecular tyrosine phosphorylation of the Tyk-2 tyrosine kinase.". FEBS Lett. 374 (3): 317–22. PMID 7589562. 
  • Yetter A, Uddin S, Krolewski JJ, et al. (1995). "Association of the interferon-dependent tyrosine kinase Tyk-2 with the hematopoietic cell phosphatase.". J. Biol. Chem. 270 (31): 18179–82. PMID 7629131. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Trask B, Fertitta A, Christensen M, et al. (1993). "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers.". Genomics 15 (1): 133–45. PMID 8432525. 
  • Platanias LC, Uddin S, Yetter A, et al. (1996). "The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2.". J. Biol. Chem. 271 (1): 278–82. PMID 8550573. 
  • Gauzzi MC, Velazquez L, McKendry R, et al. (1996). "Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase.". J. Biol. Chem. 271 (34): 20494–500. PMID 8702790. 
  • Uddin S, Gardziola C, Dangat A, et al. (1996). "Interaction of the c-cbl proto-oncogene product with the Tyk-2 protein tyrosine kinase.". Biochem. Biophys. Res. Commun. 225 (3): 833–8. doi:10.1006/bbrc.1996.1259. PMID 8780698. 
  • Zou J, Presky DH, Wu CY, Gubler U (1997). "Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta1 and beta2 and JAK kinases.". J. Biol. Chem. 272 (9): 6073–7. PMID 9038232. 
  • Miyakawa Y, Oda A, Druker BJ, et al. (1997). "Thrombopoietin and thrombin induce tyrosine phosphorylation of Vav in human blood platelets.". Blood 89 (8): 2789–98. PMID 9108397. 
  • Uddin S, Sher DA, Alsayed Y, et al. (1997). "Interaction of p59fyn with interferon-activated Jak kinases.". Biochem. Biophys. Res. Commun. 235 (1): 83–8. doi:10.1006/bbrc.1997.6741. PMID 9196040. 
  • Burfoot MS, Rogers NC, Watling D, et al. (1997). "Janus kinase-dependent activation of insulin receptor substrate 1 in response to interleukin-4, oncostatin M, and the interferons.". J. Biol. Chem. 272 (39): 24183–90. PMID 9305869. 
  • Gauzzi MC, Barbieri G, Richter MF, et al. (1997). "The amino-terminal region of Tyk2 sustains the level of interferon alpha receptor 1, a component of the interferon alpha/beta receptor.". Proc. Natl. Acad. Sci. U.S.A. 94 (22): 11839–44. PMID 9342324. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Ahmad S, Alsayed YM, Druker BJ, Platanias LC (1997). "The type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor protein.". J. Biol. Chem. 272 (48): 29991–4. PMID 9374471. 
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Kinases: tyrosine kinases (EC 2.7.10)
2.7.10.1
2.7.10.2