Tyrosine-arginine ligase

From Wikipedia, the free encyclopedia

In enzymology, a tyrosine-arginine ligase (EC 6.3.2.24) is an enzyme that catalyzes the chemical reaction

ATP + L-tyrosine + L-arginine AMP + diphosphate + L-tyrosyl-L-arginine

The 3 substrates of this enzyme are ATP, L-tyrosine, and L-arginine, whereas its 3 products are AMP, diphosphate, and L-tyrosyl-L-arginine.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is L-tyrosine:L-arginine ligase (AMP-forming). Other names in common use include tyrosyl-arginine synthase, kyotorphin synthase, kyotorphin-synthesizing enzyme, and kyotorphin synthetase.

[edit] References

• IUBMB entry for 6.3.2.24
• BRENDA references for 6.3.2.24 (Recommended.)
• PubMed references for 6.3.2.24
• PubMed Central references for 6.3.2.24
• Google Scholar references for 6.3.2.24
• Ueda H, Yoshihara Y, Fukushima N, Shiomi H, Nakamura A, Takagi H (1987). "Kyotorphin (tyrosine-arginine) synthetase in rat brain synaptosomes". J. Biol. Chem. 262: 8165–73. PMID 3597366. 

[edit] External links

The CAS registry number for this enzyme class is 116036-78-3.

• IUBMB entry for 6.3.2.24

• KEGG entry for 6.3.2.24

• BRENDA entry for 6.3.2.24

• NiceZyme view of 6.3.2.24

• EC2PDB: PDB structures for 6.3.2.24

• PRIAM entry for 6.3.2.24

• PUMA2 entry for 6.3.2.24

• IntEnz: Integrated Enzyme entry for 6.3.2.24

• MetaCyc entry for 6.3.2.24

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050367: tyrosine-arginine ligase

• AMIGO entry for GO code 0050367: tyrosine-arginine ligase