TYRP1

From Wikipedia, the free encyclopedia

Tyrosinase-related protein 1

Identifiers

TYRP1; CAS2; CATB; GP75; TRP; TYRP; b-PROTEIN

External IDs

Gene ontology
Molecular Function:	• monooxygenase activity • copper ion binding • protein binding • protein homodimerization activity • metal ion binding • protein heterodimerization activity
Cellular Component:	• membrane • integral to membrane • melanosome
Biological Process:	• melanin biosynthetic process from tyrosine • metabolic process • pigmentation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000550 (mRNA)
NP_000541 (protein)

NM_031202 (mRNA)
NP_112479 (protein)

Location

Chr 9: 12.68 - 12.7 Mb

Chr 4: 80.31 - 80.32 Mb

Pubmed search

[1]

[2]

Tyrosinase-related protein 1, also known as TYRP1, is a human gene.^[1]

[edit] References

^ Entrez Gene: TYRP1 tyrosinase-related protein 1.

[edit] Further reading

Sarangarajan R, Boissy RE (2002). "Tyrp1 and oculocutaneous albinism type 3.". Pigment Cell Res. 14 (6): 437–44. PMID 11775055.
Lowings P, Yavuzer U, Goding CR (1992). "Positive and negative elements regulate a melanocyte-specific promoter.". Mol. Cell. Biol. 12 (8): 3653–62. PMID 1321344.
Shibata K, Takeda K, Tomita Y, et al. (1992). "Downstream region of the human tyrosinase-related protein gene enhances its promoter activity.". Biochem. Biophys. Res. Commun. 184 (2): 568–75. PMID 1575733.
Murty VV, Bouchard B, Mathew S, et al. (1992). "Assignment of the human TYRP (brown) locus to chromosome region 9p23 by nonradioactive in situ hybridization.". Genomics 13 (1): 227–9. PMID 1577487.
Colman MA, Shibahara S, Kwon B, et al. (1991). "A two allele XbaI RFLP at the catalase 2 locus.". Nucleic Acids Res. 19 (4): 960. PMID 1673236.
Halaban R, Moellmann G (1990). "Murine and human b locus pigmentation genes encode a glycoprotein (gp75) with catalase activity.". Proc. Natl. Acad. Sci. U.S.A. 87 (12): 4809–13. PMID 1693779.
Abbott C, Jackson IJ, Carritt B, Povey S (1992). "The human homolog of the mouse brown gene maps to the short arm of chromosome 9 and extends the known region of homology with mouse chromosome 4.". Genomics 11 (2): 471–3. PMID 1769662.
Chintamaneni CD, Ramsay M, Colman MA, et al. (1991). "Mapping the human CAS2 gene, the homologue of the mouse brown (b) locus, to human chromosome 9p22-pter.". Biochem. Biophys. Res. Commun. 178 (1): 227–35. PMID 1906272.
Urquhart A (1991). "Human tyrosinase-like protein (TYRL) carboxy terminus: closer homology with the mouse protein than previously reported.". Nucleic Acids Res. 19 (20): 5803. PMID 1945866.
Cohen T, Muller RM, Tomita Y, Shibahara S (1990). "Nucleotide sequence of the cDNA encoding human tyrosinase-related protein.". Nucleic Acids Res. 18 (9): 2807–8. PMID 2111010.
Vijayasaradhi S, Bouchard B, Houghton AN (1990). "The melanoma antigen gp75 is the human homologue of the mouse b (brown) locus gene product.". J. Exp. Med. 171 (4): 1375–80. PMID 2324688.
Box NF, Sturm RA (1995). "Dinucleotide repeat polymorphism at the human TYRP1 locus.". Hum. Mol. Genet. 3 (12): 2270. PMID 7881448.
Orlow SJ, Zhou BK, Chakraborty AK, et al. (1994). "High-molecular-weight forms of tyrosinase and the tyrosinase-related proteins: evidence for a melanogenic complex.". J. Invest. Dermatol. 103 (2): 196–201. PMID 8040609.
Sturm RA, O'Sullivan BJ, Box NF, et al. (1996). "Chromosomal structure of the human TYRP1 and TYRP2 loci and comparison of the tyrosinase-related protein gene family.". Genomics 29 (1): 24–34. doi:10.1006/geno.1995.1211. PMID 8530077.
Boissy RE, Zhao H, Oetting WS, et al. (1996). "Mutation in and lack of expression of tyrosinase-related protein-1 (TRP-1) in melanocytes from an individual with brown oculocutaneous albinism: a new subtype of albinism classified as "OCA3".". Am. J. Hum. Genet. 58 (6): 1145–56. PMID 8651291.
Manga P, Kromberg JG, Box NF, et al. (1997). "Rufous oculocutaneous albinism in southern African Blacks is caused by mutations in the TYRP1 gene.". Am. J. Hum. Genet. 61 (5): 1095–101. PMID 9345097.
Box NF, Wyeth JR, Mayne CJ, et al. (1998). "Complete sequence and polymorphism study of the human TYRP1 gene encoding tyrosinase-related protein 1.". Mamm. Genome 9 (1): 50–3. PMID 9434945.
Bertolotto C, Buscà R, Abbe P, et al. (1998). "Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmia.". Mol. Cell. Biol. 18 (2): 694–702. PMID 9447965.
Abe T, Sato M, Tamai M (1999). "Dedifferentiation of the retinal pigment epithelium compared to the proliferative membranes of proliferative vitreoretinopathy.". Curr. Eye Res. 17 (12): 1103–9. PMID 9872531.
Commo S, Bernard BA (2000). "Melanocyte subpopulation turnover during the human hair cycle: an immunohistochemical study.". Pigment Cell Res. 13 (4): 253–9. PMID 10952393.