TYRO3

From Wikipedia, the free encyclopedia

TYRO3 protein tyrosine kinase

PDB rendering based on 1rhf.

Available structures: 1rhf

Identifiers

Symbol(s)

TYRO3; BYK; Brt; Dtk; RSE; Sky; Tif

External IDs

OMIM: 600341 MGI: 104294 HomoloGene: 4585

Gene ontology
Molecular Function:	• nucleotide binding • transmembrane receptor protein tyrosine kinase activity • receptor signaling protein tyrosine kinase activity • receptor activity • protein binding • ATP binding • transferase activity
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• protein amino acid phosphorylation • cell adhesion • signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006293 (mRNA)
NP_006284 (protein)

XM_001003157 (mRNA)
XP_001003157 (protein)

Location

Chr 15: 39.64 - 39.66 Mb

Chr 2: 119.49 - 119.51 Mb

Pubmed search

[1]

[2]

TYRO3 protein tyrosine kinase, also known as TYRO3, is a human gene.^[1]

[edit] References

^ Entrez Gene: TYRO3 TYRO3 protein tyrosine kinase.

[edit] Further reading

Mark MR, Scadden DT, Wang Z, et al. (1994). "rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain.". J. Biol. Chem. 269 (14): 10720–8. PMID 7511603.
Toshima J, Ohashi K, Iwashita S, Mizuno K (1995). "Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase.". Biochem. Biophys. Res. Commun. 209 (2): 656–63. doi:10.1006/bbrc.1995.1549. PMID 7537495.
Richard I, Broux O, Chiannilkulchai N, et al. (1995). "Regional localization of human chromosome 15 loci.". Genomics 23 (3): 619–27. PMID 7851890.
Crosier KE, Hall LR, Lewis PM, et al. (1995). "Isolation and characterization of the human DTK receptor tyrosine kinase.". Growth Factors 11 (2): 137–44. PMID 7857658.
Ohashi K, Mizuno K, Kuma K, et al. (1994). "Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain.". Oncogene 9 (3): 699–705. PMID 8108112.
Dai W, Pan H, Hassanain H, et al. (1994). "Molecular cloning of a novel receptor tyrosine kinase, tif, highly expressed in human ovary and testis.". Oncogene 9 (3): 975–9. PMID 8108143.
Polvi A, Armstrong E, Lai C, et al. (1994). "The human TYRO3 gene and pseudogene are located in chromosome 15q14-q25.". Gene 134 (2): 289–93. PMID 8262388.
Mark MR, Chen J, Hammonds RG, et al. (1996). "Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl.". J. Biol. Chem. 271 (16): 9785–9. PMID 8621659.
Crosier PS, Freeman SA, Orlic D, et al. (1996). "The Dtk receptor tyrosine kinase, which binds protein S, is expressed during hematopoiesis.". Exp. Hematol. 24 (2): 318–23. PMID 8641360.
Nagata K, Ohashi K, Nakano T, et al. (1997). "Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases.". J. Biol. Chem. 271 (47): 30022–7. PMID 8939948.
Kajii Y, Ninomiya D, Kato M, et al. (1997). "A tyrosine kinase-like molecule is localized in the nuclear membrane of neurons: hippocampal behavior under stress.". Biol. Cell 88 (1-2): 45–54. PMID 9175267.
Lan Z, Wu H, Li W, et al. (2000). "Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway.". Blood 95 (2): 633–8. PMID 10627473.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Yin JL, Hambly BD, Bao SS, et al. (2004). "Expression of growth arrest-specific gene 6 and its receptors in dysfunctional human renal allografts.". Transpl. Int. 16 (9): 681–8. doi:10.1007/s00147-003-0593-3. PMID 12768229.
Heiring C, Dahlbäck B, Muller YA (2004). "Ligand recognition and homophilic interactions in Tyro3: structural insights into the Axl/Tyro3 receptor tyrosine kinase family.". J. Biol. Chem. 279 (8): 6952–8. doi:10.1074/jbc.M311750200. PMID 14623883.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Gould WR, Baxi SM, Schroeder R, et al. (2005). "Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses.". J. Thromb. Haemost. 3 (4): 733–41. doi:10.1111/j.1538-7836.2005.01186.x. PMID 15733062.
Hafizi S, Gustafsson A, Stenhoff J, Dahlbäck B (2005). "The Ran binding protein RanBPM interacts with Axl and Sky receptor tyrosine kinases.". Int. J. Biochem. Cell Biol. 37 (11): 2344–56. doi:10.1016/j.biocel.2005.05.006. PMID 15964779.
Shimojima M, Takada A, Ebihara H, et al. (2006). "Tyro3 family-mediated cell entry of Ebola and Marburg viruses.". J. Virol. 80 (20): 10109–16. doi:10.1128/JVI.01157-06. PMID 17005688.