TXNRD1

From Wikipedia, the free encyclopedia

Thioredoxin reductase 1

PDB rendering based on 1h6v.

Available structures: 1h6v, 2cfy

Identifiers

Symbol(s)

TXNRD1; TR; TR1; GRIM-12; MGC9145; TRXR1; TXNR

External IDs

OMIM: 601112 MGI: 1354175 HomoloGene: 55733

EC number

1.8.1.9

Gene ontology
Molecular Function:	• thioredoxin-disulfide reductase activity • selenium binding • disulfide oxidoreductase activity • oxidoreductase activity • oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor • FAD binding • NADP binding
Cellular Component:	• cytoplasm
Biological Process:	• electron transport • signal transduction • cell redox homeostasis

Orthologs

Human

Mouse

Refseq

NM_003330 (mRNA)
NP_003321 (protein)

NM_001042513 (mRNA)
NP_001035978 (protein)

Location

n/a

Chr 10: 82.3 - 82.33 Mb

Pubmed search

[1]

[2]

Thioredoxin reductase 1, also known as TXNRD1, is a human gene.

This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms.^[1]