TXNL4A

From Wikipedia, the free encyclopedia

Thioredoxin-like 4A

PDB rendering based on 1pqn.

Available structures: 1pqn, 1qgv, 1syx

Identifiers

Symbol(s)

TXNL4A; DIB1; DIM1; HsT161; TXNL4; U5-15kD

External IDs

MGI: 1351613 HomoloGene: 7150

Gene ontology
Molecular Function:	• RNA splicing factor activity, transesterification mechanism
Cellular Component:	• nucleus • spliceosome
Biological Process:	• spliceosome assembly • mRNA processing • cell cycle • mitosis • RNA splicing • cell division

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_006701 (mRNA)
NP_006692 (protein)

NM_001038608 (mRNA)
NP_001033697 (protein)

Location

Chr 18: 75.83 - 75.85 Mb

n/a

Pubmed search

[1]

[2]

Thioredoxin-like 4A, also known as TXNL4A, is a human gene.^[1]

[edit] References

^ Entrez Gene: TXNL4A thioredoxin-like 4A.

[edit] Further reading

Reuter K, Nottrott S, Fabrizio P, et al. (2000). "Identification, characterization and crystal structure analysis of the human spliceosomal U5 snRNP-specific 15 kD protein.". J. Mol. Biol. 294 (2): 515-25. doi:10.1006/jmbi.1999.3258. PMID 10610776.
Zhang YZ, Gould KL, Dunbrack RL JR, et al. (2001). "The evolutionarily conserved Dim1 protein defines a novel branch of the thioredoxin fold superfamily.". Physiol. Genomics 1 (3): 109-18. PMID 11015569.
Zhang Y, Lindblom T, Chang A, et al. (2001). "Evidence that dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for dim1 interactions with hnRNP F and Npw38/PQBP-1.". Gene 257 (1): 33-43. PMID 11054566.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Zhang YZ, Cheng H, Gould KL, et al. (2003). "Structure, stability, and function of hDim1 investigated by NMR, circular dichroism, and mutational analysis.". Biochemistry 42 (32): 9609-18. doi:10.1021/bi034486i. PMID 12911302.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Laggerbauer B, Liu S, Makarov E, et al. (2005). "The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation.". RNA 11 (5): 598-608. doi:10.1261/rna.2300805. PMID 15840814.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Jin T, Guo F, Wang Y, Zhang YZ (2007). "Identification of human dim1 as a peptidase with autocleavage activity.". Chemical biology & drug design 68 (5): 266-72. doi:10.1111/j.1747-0285.2006.00447.x. PMID 17177886.