TXNIP

From Wikipedia, the free encyclopedia

Thioredoxin interacting protein

Identifiers

TXNIP; EST01027; HHCPA78; THIF; VDUP1

External IDs

OMIM: 606599 MGI: 1889549 HomoloGene: 38186

Gene ontology
Molecular Function:	• enzyme inhibitor activity • protein binding
Cellular Component:	• cytoplasm
Biological Process:	• response to oxidative stress • keratinocyte differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006472 (mRNA)
NP_006463 (protein)

NM_001009935 (mRNA)
NP_001009935 (protein)

Location

Chr 1: 144.15 - 144.15 Mb

Chr 3: 96.64 - 96.66 Mb

Pubmed search

[1]

[2]

Thioredoxin interacting protein, also known as TXNIP, is a human gene.^[1]

[edit] References

^ Entrez Gene: TXNIP thioredoxin interacting protein.

[edit] Further reading

Chen KS, DeLuca HF (1994). "Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3.". Biochim. Biophys. Acta 1219 (1): 26-32. PMID 8086474.
Nishiyama A, Matsui M, Iwata S, et al. (1999). "Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression.". J. Biol. Chem. 274 (31): 21645-50. PMID 10419473.
Ludwig DL, Kotanides H, Le T, et al. (2001). "Cloning, genetic characterization, and chromosomal mapping of the mouse VDUP1 gene.". Gene 269 (1-2): 103-12. PMID 11376942.
Bodnar JS, Chatterjee A, Castellani LW, et al. (2002). "Positional cloning of the combined hyperlipidemia gene Hyplip1.". Nat. Genet. 30 (1): 110-6. doi:10.1038/ng811. PMID 11753387.
Joguchi A, Otsuka I, Minagawa S, et al. (2002). "Overexpression of VDUP1 mRNA sensitizes HeLa cells to paraquat.". Biochem. Biophys. Res. Commun. 293 (1): 293-7. doi:10.1016/S0006-291X(02)00208-5. PMID 12054598.
Butler LM, Zhou X, Xu WS, et al. (2002). "The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin.". Proc. Natl. Acad. Sci. U.S.A. 99 (18): 11700-5. doi:10.1073/pnas.182372299. PMID 12189205.
Schulze PC, De Keulenaer GW, Yoshioka J, et al. (2002). "Vitamin D3-upregulated protein-1 (VDUP-1) regulates redox-dependent vascular smooth muscle cell proliferation through interaction with thioredoxin.". Circ. Res. 91 (8): 689-95. PMID 12386145.
Han SH, Jeon JH, Ju HR, et al. (2003). "VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression.". Oncogene 22 (26): 4035-46. doi:10.1038/sj.onc.1206610. PMID 12821938.
Champliaud MF, Viel A, Baden HP (2003). "The expression of vitamin D-upregulated protein 1 in skin and its interaction with sciellin in cultured keratinocytes.". J. Invest. Dermatol. 121 (4): 781-5. doi:10.1046/j.1523-1747.2003.12539.x. PMID 14632196.
Kim KY, Shin SM, Kim JK, et al. (2004). "Heat shock factor regulates VDUP1 gene expression.". Biochem. Biophys. Res. Commun. 315 (2): 369-75. doi:10.1016/j.bbrc.2004.01.047. PMID 14766217.
Schulze PC, Yoshioka J, Takahashi T, et al. (2004). "Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein.". J. Biol. Chem. 279 (29): 30369-74. doi:10.1074/jbc.M400549200. PMID 15128745.
Coon H, Singh N, Dunn D, et al. (2004). "TXNIP gene not associated with familial combined hyperlipidemia in the NHLBI Family Heart Study.". Atherosclerosis 174 (2): 357-62. doi:10.1016/j.atherosclerosis.2004.02.004. PMID 15136067.
Nishinaka Y, Masutani H, Oka S, et al. (2004). "Importin alpha1 (Rch1) mediates nuclear translocation of thioredoxin-binding protein-2/vitamin D(3)-up-regulated protein 1.". J. Biol. Chem. 279 (36): 37559-65. doi:10.1074/jbc.M405473200. PMID 15234975.
Aitken CJ, Hodge JM, Nishinaka Y, et al. (2005). "Regulation of human osteoclast differentiation by thioredoxin binding protein-2 and redox-sensitive signaling.". J. Bone Miner. Res. 19 (12): 2057-64. doi:10.1359/JBMR.040913. PMID 15537450.
Yamawaki H, Pan S, Lee RT, Berk BC (2005). "Fluid shear stress inhibits vascular inflammation by decreasing thioredoxin-interacting protein in endothelial cells.". J. Clin. Invest. 115 (3): 733-8. doi:10.1172/JCI200523001. PMID 15696199.
Minn AH, Hafele C, Shalev A (2005). "Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis.". Endocrinology 146 (5): 2397-405. doi:10.1210/en.2004-1378. PMID 15705778.