TXNDC4

From Wikipedia, the free encyclopedia

Thioredoxin domain containing 4 (endoplasmic reticulum)

Identifiers

TXNDC4; ERP44; KIAA0573

External IDs

OMIM: 609170 MGI: 1923549 HomoloGene: 12638

Gene ontology
Molecular Function:	• protein disulfide isomerase activity • protein binding • electron carrier activity • protein disulfide oxidoreductase activity
Cellular Component:	• endoplasmic reticulum • endoplasmic reticulum lumen • endoplasmic reticulum membrane • ER-Golgi intermediate compartment
Biological Process:	• protein folding • response to unfolded protein • glycoprotein metabolic process • regulation of cell redox homeostasis • secretory pathway

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_015051 (mRNA)
NP_055866 (protein)

NM_029572 (mRNA)
NP_083848 (protein)

Location

n/a

Chr 4: 48.21 - 48.3 Mb

Pubmed search

[1]

[2]

Thioredoxin domain containing 4 (endoplasmic reticulum), also known as TXNDC4, is a human gene.^[1]

[edit] References

^ Entrez Gene: TXNDC4 thioredoxin domain containing 4 (endoplasmic reticulum).

[edit] Further reading

Anelli T, Ceppi S, Bergamelli L, et al. (2007). "Sequential steps and checkpoints in the early exocytic compartment during secretory IgM biogenesis.". EMBO J. 26 (19): 4177–88. doi:10.1038/sj.emboj.7601844. PMID 17805346.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Otsu M, Bertoli G, Fagioli C, et al. (2006). "Dynamic retention of Ero1alpha and Ero1beta in the endoplasmic reticulum by interactions with PDI and ERp44.". Antioxid. Redox Signal. 8 (3-4): 274–82. doi:10.1089/ars.2006.8.274. PMID 16677073.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Higo T, Hattori M, Nakamura T, et al. (2005). "Subtype-specific and ER lumenal environment-dependent regulation of inositol 1,4,5-trisphosphate receptor type 1 by ERp44.". Cell 120 (1): 85–98. doi:10.1016/j.cell.2004.11.048. PMID 15652484.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Breuza L, Halbeisen R, Jenö P, et al. (2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46.". J. Biol. Chem. 279 (45): 47242–53. doi:10.1074/jbc.M406644200. PMID 15308636.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053.
Anelli T, Alessio M, Bachi A, et al. (2003). "Thiol-mediated protein retention in the endoplasmic reticulum: the role of ERp44.". EMBO J. 22 (19): 5015–22. doi:10.1093/emboj/cdg491. PMID 14517240.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
O'Neill EE, Brock CJ, von Kriegsheim AF, et al. (2002). "Towards complete analysis of the platelet proteome.". Proteomics 2 (3): 288–305. PMID 11921445.
Anelli T, Alessio M, Mezghrani A, et al. (2002). "ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family.". EMBO J. 21 (4): 835–44. doi:10.1093/emboj/21.4.835. PMID 11847130.
Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (1): 31–9. PMID 9628581.