TXNDC12

From Wikipedia, the free encyclopedia

Thioredoxin domain containing 12 (endoplasmic reticulum)

PDB rendering based on 1sen.

Available structures: 1sen

Identifiers

Symbol(s)

TXNDC12; AGR1; ERP18; ERP19; TLP19; hAG-1

External IDs

OMIM: 609448 MGI: 1913323 HomoloGene: 41074

Gene ontology
Molecular Function:	• electron carrier activity • protein disulfide oxidoreductase activity • protein-disulfide reductase (glutathione) activity
Cellular Component:	• endoplasmic reticulum
Biological Process:	• cell redox homeostasis

Orthologs

Human

Mouse

Refseq

NM_015913 (mRNA)
NP_056997 (protein)

NM_025334 (mRNA)
NP_079610 (protein)

Location

Chr 1: 52.26 - 52.29 Mb

Chr 4: 108.33 - 108.36 Mb

Pubmed search

[1]

[2]

Thioredoxin domain containing 12 (endoplasmic reticulum), also known as TXNDC12, is a human gene.^[1]

TXNDC12 belongs to the thioredoxin superfamily (see TXN; MIM 187700). Members of this superfamily possess a thioredoxin fold with a consensus active-site sequence (CxxC) and have roles in redox regulation, defense against oxidative stress, refolding of disulfide-containing proteins, and regulation of transcription factors (Liu et al., 2003).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: TXNDC12 thioredoxin domain containing 12 (endoplasmic reticulum).

[edit] Further reading

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107-13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353-8. PMID 9110174.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Alanen HI, Williamson RA, Howard MJ, et al. (2003). "Functional characterization of ERp18, a new endoplasmic reticulum-located thioredoxin superfamily member.". J. Biol. Chem. 278 (31): 28912-20. doi:10.1074/jbc.M304598200. PMID 12761212.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309.
Liu F, Rong YP, Zeng LC, et al. (2004). "Isolation and characterization of a novel human thioredoxin-like gene hTLP19 encoding a secretory protein.". Gene 315: 71-8. PMID 14557066.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819-24. doi:10.1110/ps.04682504. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117-26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315-21. doi:10.1038/nature04727. PMID 16710414.