TXN2

From Wikipedia, the free encyclopedia

Thioredoxin 2

PDB rendering based on 1uvz.

Available structures: 1uvz, 1w4v, 1w89

Identifiers

Symbol(s)

TXN2; TRX2; MT-TRX; MTRX

External IDs

OMIM: 609063 MGI: 1929468 HomoloGene: 40849

Gene ontology
Molecular Function:	• electron carrier activity • protein disulfide oxidoreductase activity • thiol-disulfide exchange intermediate activity
Cellular Component:	• mitochondrion
Biological Process:	• electron transport • glycerol ether metabolic process • transport • cell redox homeostasis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012473 (mRNA)
NP_036605 (protein)

NM_019913 (mRNA)
NP_064297 (protein)

Location

Chr 22: 35.19 - 35.21 Mb

Chr 15: 77.74 - 77.76 Mb

Pubmed search

[1]

[2]

Thioredoxin 2, also known as TXN2, is a human gene.^[1]

This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis.^[1]

[edit] References

^ ^a ^b Entrez Gene: TXN2 thioredoxin 2.

[edit] Further reading

Wang Z, Zhang H, Li XF, Le XC (2007). "Study of interactions between arsenicals and thioredoxins (human and E. coli) using mass spectrometry.". Rapid Commun. Mass Spectrom. 21 (22): 3658–66. doi:10.1002/rcm.3263. PMID 17939155.
Udler M, Maia AT, Cebrian A, et al. (2007). "Common germline genetic variation in antioxidant defense genes and survival after diagnosis of breast cancer.". J. Clin. Oncol. 25 (21): 3015–23. doi:10.1200/JCO.2006.10.0099. PMID 17634480.
Zhang H, Go YM, Jones DP (2007). "Mitochondrial thioredoxin-2/peroxiredoxin-3 system functions in parallel with mitochondrial GSH system in protection against oxidative stress.". Arch. Biochem. Biophys. 465 (1): 119–26. doi:10.1016/j.abb.2007.05.001. PMID 17548047.
Zhou J, Damdimopoulos AE, Spyrou G, Brüne B (2007). "Thioredoxin 1 and thioredoxin 2 have opposed regulatory functions on hypoxia-inducible factor-1alpha.". J. Biol. Chem. 282 (10): 7482–90. doi:10.1074/jbc.M608289200. PMID 17220299.
Oestergaard MZ, Tyrer J, Cebrian A, et al. (2006). "Interactions between genes involved in the antioxidant defence system and breast cancer risk.". Br. J. Cancer 95 (4): 525–31. doi:10.1038/sj.bjc.6603272. PMID 16868544.
Cebrian A, Pharoah PD, Ahmed S, et al. (2006). "Tagging single-nucleotide polymorphisms in antioxidant defense enzymes and susceptibility to breast cancer.". Cancer Res. 66 (2): 1225–33. doi:10.1158/0008-5472.CAN-05-1857. PMID 16424062.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Damdimopoulos AE, Miranda-Vizuete A, Pelto-Huikko M, et al. (2002). "Human mitochondrial thioredoxin. Involvement in mitochondrial membrane potential and cell death.". J. Biol. Chem. 277 (36): 33249–57. doi:10.1074/jbc.M203036200. PMID 12080052.
Chen Y, Cai J, Murphy TJ, Jones DP (2002). "Overexpressed human mitochondrial thioredoxin confers resistance to oxidant-induced apoptosis in human osteosarcoma cells.". J. Biol. Chem. 277 (36): 33242–8. doi:10.1074/jbc.M202026200. PMID 12032145.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Spyrou G, Enmark E, Miranda-Vizuete A, Gustafsson J (1997). "Cloning and expression of a novel mammalian thioredoxin.". J. Biol. Chem. 272 (5): 2936–41. PMID 9006939.