Two-pore channel

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two pore segment channel 1
Identifiers
Symbol TPCN1
Entrez 53373
HUGO 18182
OMIM 609666
RefSeq NM_017901
UniProt Q9ULQ1
Other data
Locus Chr. 12 q24.21
two pore segment channel 2
Identifiers
Symbol TPCN2
Entrez 219931
HUGO 20820
RefSeq NM_139075
UniProt Q8NHX9
Other data
Locus Chr. 11 q13.1

Two-pore channels: This small family of 2 members putatively forms cation-selective ion channels. They are predicted to contain two KV-style six-transmembrane domains, suggesting they form a dimer in the membrane. These channels are related to catsper channels channels and, more distantly, TRP channels.

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Membrane transport protein: ion channels
Ca2+: Calcium channel
Voltage-dependent calcium channel (L-type/Cavα(1.1, 1.2, 1.3, 1.4), N-type, P-type/Cavα(2.1), Q-type, R-type, T-type, α2δ-subunits (1, 2), β-subunits (β1, β2, β3, β4), γ-subunits (γ1, γ2, γ3, γ4)
Inositol triphosphate receptor • Ryanodine receptor • Cation channels of sperm • Two-pore channel
Na+: Sodium channel
Navα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.9, 7A) • Navβ (1, 2, 3, 4) • Epithelial sodium channel
K+: Potassium channel
Cl-: Chloride channel
Porin
Cations: TRP
TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (Mucolipin-1) • TRPP (1, 2) • TRPV (1, 2, 3, 4, 5, 6)
Other/general