TUSC3

From Wikipedia, the free encyclopedia

Tumor suppressor candidate 3

Identifiers

TUSC3; D8S1992; MGC13453; N33; OST3A

External IDs

OMIM: 601385 MGI: 1933134 HomoloGene: 6937

Gene ontology
Molecular Function:	• dolichyl-diphosphooligosaccharide-protein glycotransferase activity
Cellular Component:	• mitochondrion • endoplasmic reticulum • oligosaccharyl transferase complex • membrane • integral to membrane
Biological Process:	• protein amino acid N-linked glycosylation via asparagine

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_006765 (mRNA)
NP_006756 (protein)

NM_030254 (mRNA)
NP_084530 (protein)

Location

Chr 8: 15.44 - 15.67 Mb

Chr 8: 40.47 - 40.67 Mb

Pubmed search

[1]

[2]

Tumor suppressor candidate 3, also known as TUSC3, is a human gene.^[1]

This gene is a candidate tumor suppressor gene. It is located within a homozygously deleted region of a metastatic prostate cancer. The gene is expressed in most nonlymphoid human tissues including prostate, lung, liver, and colon. Expression was also detected in many epithelial tumor cell lines. Two transcript variants encoding distinct isoforms have been identified for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: TUSC3 tumor suppressor candidate 3.

[edit] Further reading

MacGrogan D, Levy A, Bova GS, et al. (1996). "Structure and methylation-associated silencing of a gene within a homozygously deleted region of human chromosome band 8p22.". Genomics 35 (1): 55–65. doi:10.1006/geno.1996.0322. PMID 8661104.
Pak BJ, Park H, Chang ER, et al. (1998). "Differential display analysis of oxygen-mediated changes in gene expression in first trimester human trophoblast cells.". Placenta 19 (7): 483–8. PMID 9778121.
Ishii H, Baffa R, Numata SI, et al. (1999). "The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors.". Proc. Natl. Acad. Sci. U.S.A. 96 (7): 3928–33. PMID 10097140.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Kelleher DJ, Karaoglu D, Mandon EC, Gilmore R (2003). "Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties.". Mol. Cell 12 (1): 101–11. PMID 12887896.
Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources.". Mol. Cell Proteomics 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Shibatani T, David LL, McCormack AL, et al. (2005). "Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits.". Biochemistry 44 (16): 5982–92. doi:10.1021/bi047328f. PMID 15835887.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Pils D, Horak P, Gleiss A, et al. (2006). "Five genes from chromosomal band 8p22 are significantly down-regulated in ovarian carcinoma: N33 and EFA6R have a potential impact on overall survival.". Cancer 104 (11): 2417–29. doi:10.1002/cncr.21538. PMID 16270321.
Guervós MA, Marcos CA, Hermsen M, et al. (2007). "Deletions of N33, STK11 and TP53 are involved in the development of lymph node metastasis in larynx and pharynx carcinomas.". Cell. Oncol. 29 (4): 327–34. PMID 17641416.