TUSC2

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Tumor suppressor candidate 2
Identifiers
Symbol(s) TUSC2; PAP; FUS1; C3orf11; PDAP2
External IDs OMIM: 607052 MGI: 1931086 HomoloGene: 5264
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 11334 80385
Ensembl ENSG00000114383 ENSMUSG00000010054
Uniprot O75896 Q542N4
Refseq NM_007275 (mRNA)
NP_009206 (protein)		 NM_019742 (mRNA)
NP_062716 (protein)
Location Chr 3: 50.34 - 50.34 Mb Chr 9: 107.42 - 107.42 Mb
Pubmed search [1] [2]

Tumor suppressor candidate 2, also known as TUSC2, is a human gene.[1]

This gene is a highly conserved lung cancer candidate gene. No other information about this gene is currently available.[1]

[edit] References

  1. ^ a b Entrez Gene: TUSC2 tumor suppressor candidate 2.

[edit] Further reading

  • Prudkin L, Behrens C, Liu DD, et al. (2008). "Loss and reduction of FUS1 protein expression is a frequent phenomenon in the pathogenesis of lung cancer.". Clin. Cancer Res. 14 (1): 41–7. doi:10.1158/1078-0432.CCR-07-1252. PMID 18172250. 
  • Lee DY, Deng Z, Wang CH, Yang BB (2008). "MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expression.". Proc. Natl. Acad. Sci. U.S.A. 104 (51): 20350–5. doi:10.1073/pnas.0706901104. PMID 18077375. 
  • Lin J, Sun T, Ji L, et al. (2007). "Oncogenic activation of c-Abl in non-small cell lung cancer cells lacking FUS1 expression: inhibition of c-Abl by the tumor suppressor gene product Fus1.". Oncogene 26 (49): 6989–96. doi:10.1038/sj.onc.1210500. PMID 17486070. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Uno F, Sasaki J, Nishizaki M, et al. (2004). "Myristoylation of the fus1 protein is required for tumor suppression in human lung cancer cells.". Cancer Res. 64 (9): 2969–76. PMID 15126327. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Kondo M, Ji L, Kamibayashi C, et al. (2001). "Overexpression of candidate tumor suppressor gene FUS1 isolated from the 3p21.3 homozygous deletion region leads to G1 arrest and growth inhibition of lung cancer cells.". Oncogene 20 (43): 6258–62. doi:10.1038/sj.onc.1204832. PMID 11593436. 
  • Lerman MI, Minna JD (2000). "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium.". Cancer Res. 60 (21): 6116–33. PMID 11085536. 
  • Fischer WH, Schubert D (1997). "Characterization of a novel platelet-derived growth factor-associated protein.". J. Neurochem. 66 (5): 2213–6. PMID 8780057. 
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