Tumor necrosis factor receptor

From Wikipedia, the free encyclopedia

TNFR/NGFR cysteine-rich region
Identifiers
Symbol TNFR_c6
Pfam PF00020
InterPro IPR011614
PROSITE PDOC00561
SCOP 1tnr
Available PDB structures:

1d0g, 1du3, 1ext, 1ft4, 1jma, 1ncf, 1sg1, 1tnr, 1za3, 2aw2

A tumor necrosis factor receptor (TNFR), or death receptor, is a cytokine receptor that binds tumor necrosis factors (TNF).

Because "TNF" is often used to describe TNF alpha, "TNFR" is often used to describe the receptors that bind to TNF alpha - namely, CD120. However, there several other members of this family that bind to the other TNFs.[1][2]

[edit] Members

Family members include:[1]

[edit] References

  1. ^ a b Locksley RM, Killeen N, Lenardo MJ (2001). "The TNF and TNF receptor superfamilies: integrating mammalian biology". Cell 104 (4): 487–501. doi:10.1016/S0092-8674(01)00237-9. PMID 11239407. 
  2. ^ Hehlgans T, Pfeffer K (2005). "The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games". Immunology 115 (1): 1–20. doi:10.1111/j.1365-2567.2005.02143.x. PMID 15819693. 

[edit] External links

 This biochemistry article is a stub. You can help Wikipedia by expanding it.
v • d • e
Transmembrane receptors: immune receptors
Cytokine receptor
Pattern recognition/Toll-like
Fc receptor
Lymphocyte homing receptor
other
v • d • e
Cytokine receptors: tumor necrosis factor receptor superfamily
1-10
11-20
21-25