Tubulin-tyrosine ligase

From Wikipedia, the free encyclopedia

In enzymology, a tubulin-tyrosine ligase (EC 6.3.2.25) is an enzyme that catalyzes the chemical reaction

ATP + detyrosinated alpha-tubulin + L-tyrosine alpha-tubulin + ADP + phosphate

The 3 substrates of this enzyme are ATP, detyrosinated alpha-tubulin, and L-tyrosine, whereas its 3 products are alpha-tubulin, ADP, and phosphate.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is alpha-tubulin:L-tyrosine ligase (ADP-forming).

[edit] References

• IUBMB entry for 6.3.2.25
• BRENDA references for 6.3.2.25 (Recommended.)
• PubMed references for 6.3.2.25
• PubMed Central references for 6.3.2.25
• Google Scholar references for 6.3.2.25
• Wehland J, Schroder HC, Weber K (1986). "Isolation and purification of tubulin tyrosine ligase". Methods. Enzymol. 134: 170–9. PMID 3821560. 
• Rudiger M, Wehland J, Weber K (1994). "The carboxy-terminal peptide of detyrosinated alpha tubulin provides a minimal system to study the substrate specificity of tubulin-tyrosine ligase". Eur. J. Biochem. 220: 309–20. doi:10.1111/j.1432-1033.1994.tb18627.x. PMID 7510228. 

[edit] External links

The CAS registry number for this enzyme class is 60321-03-1.

• IUBMB entry for 6.3.2.25

• KEGG entry for 6.3.2.25

• BRENDA entry for 6.3.2.25

• NiceZyme view of 6.3.2.25

• EC2PDB: PDB structures for 6.3.2.25

• PRIAM entry for 6.3.2.25

• PUMA2 entry for 6.3.2.25

• IntEnz: Integrated Enzyme entry for 6.3.2.25

• MetaCyc entry for 6.3.2.25

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004835: tubulin-tyrosine ligase

• AMIGO entry for GO code 0004835: tubulin-tyrosine ligase