Tubocurarine

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Tubocurarine
Systematic (IUPAC) name
?
Identifiers
CAS number	57-94-3
ATC code	M03AA02 M03 AA04
PubChem	6000
DrugBank	APRD00176
Chemical data
Formula	C₃₇H₄₁N₂O₆
Mol. mass	609.731 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	50%
Metabolism	?
Half life	1-2 Hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	banned
Routes	I.V.

Tubocurarine chloride is a mixed antagonist of nicotinic neuromuscular acetylcholine receptors, used to paralyse patients undergoing anaesthesia. It is one of the chemicals that can be obtained from curare, itself an extract of Chondrodendron tomentosum, a plant found in South American jungles which is used as a source of arrow poison. Native indians hunting animals with this poison were able to eat the animal's contaminated flesh without being affected by the toxin because tubocurarine cannot easily cross mucous membranes and is thus inactive orally.

Medically, first used in 1912. Introduced in anaesthesia in 1942. The correct chemical structure was only elucidated circa 1970, even though the plant had been known since the Spanish Conquest.

The word curare comes from the South American Indian name for the arrow poison: "ourare". Presumably the initial syllable was pronounced with a heavy glottal stroke. Tubocurarine is so called because the plant samples containing it were first shipped to Europe in tubes.

Today, tubocurarine has fallen into disuse in western medicine, as safer synthetic alternatives such as atracurium are available. However, tubocurarine is still used in the United States and elsewhere as part of the lethal injection procedure.

[edit] Other names

d-Tubocurarine. Tubocurarin. Tubocurarinum. Delacurarine. Tubarine. Metubine. Jex

HSDB 2152. Isoquinoline Alkaloid. Tubadil. Mecostrin. Intracostin. Intocostrin.

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v • d • e

Skeletal Muscle relaxants (M03)

Peripherally acting
(primarily antinicotinic,
neuromuscular-blocking drugs)

Curare Alkaloids (Non-Depolarising)	Alcuronium, Dimethyltubocurarine, Tubocurarine

quaternary ammonium compounds (Non-Depolarising)	Atracurium, Cisatracurium, Doxacurium chloride, Fazadinium bromide, Gallamine, Hexafluronium, Metocurine, Mivacurium chloride, Pancuronium, Pipecuronium bromide, Rocuronium bromide,Vecuronium

Choline Derivatives (Depolarising)	Suxamethonium, Succinylcholine

Other	Botulinum toxin