Tuberculous lymphadenitis

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Tuberculous lymphadenitis is a chronic specific granulomatous inflammation with caseation necrosis.

Histopathology: The characteristic morphological element is the tuberculous granuloma (caseating tubercule): giant multinucleated cells (Langerhans cells), surrounded by epithelioid cells aggregates, T cell lymphocytes and few fibroblasts. Granulomatous tubercules evolve to central caseous necrosis and tend to become confluent, replacing the lymphoid tissue. Photo at: Atlas of Pathology

History: In the Middle Ages, this was either called the Black Death or the King's Evil. It was thought that King George I could cure someone with his touch.