TUB (gene)

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Tubby homolog (mouse)
PDB rendering based on 1c8z.
Available structures: 1c8z, 1i7e, 1s31
Identifiers
Symbol(s) TUB; rd5
External IDs OMIM: 601197 MGI: 2651573 HomoloGene: 31147
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 7275 22141
Ensembl ENSG00000166402 ENSMUSG00000031028
Uniprot P50607 Q3TMT9
Refseq NM_003320 (mRNA)
NP_003311 (protein)		 NM_021885 (mRNA)
NP_068685 (protein)
Location Chr 11: 8.02 - 8.08 Mb Chr 7: 108.74 - 108.83 Mb
Pubmed search [1] [2]

Tubby homolog (mouse), also known as TUB, is a human gene.[1]

This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis. Two transcript variants encoding distinct isoforms have been identified for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: TUB tubby homolog (mouse).

[edit] Further reading

  • Ikeda A, Nishina PM, Naggert JK (2002). "The tubby-like proteins, a family with roles in neuronal development and function.". J. Cell. Sci. 115 (Pt 1): 9–14. PMID 11801719. 
  • Jones JM, Meisler MH, Seldin MF, et al. (1992). "Localization of insulin-2 (Ins-2) and the obesity mutant tubby (tub) to distinct regions of mouse chromosome 7.". Genomics 14 (1): 197–9. PMID 1358794. 
  • Kleyn PW, Fan W, Kovats SG, et al. (1996). "Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family.". Cell 85 (2): 281–90. PMID 8612280. 
  • North MA, Naggert JK, Yan Y, et al. (1997). "Molecular characterization of TUB, TULP1, and TULP2, members of the novel tubby gene family and their possible relation to ocular diseases.". Proc. Natl. Acad. Sci. U.S.A. 94 (7): 3128–33. PMID 9096357. 
  • Kapeller R, Moriarty A, Strauss A, et al. (1999). "Tyrosine phosphorylation of tub and its association with Src homology 2 domain-containing proteins implicate tub in intracellular signaling by insulin.". J. Biol. Chem. 274 (35): 24980–6. PMID 10455176. 
  • Boggon TJ, Shan WS, Santagata S, et al. (1999). "Implication of tubby proteins as transcription factors by structure-based functional analysis.". Science 286 (5447): 2119–25. PMID 10591637. 
  • He W, Ikeda S, Bronson RT, et al. (2001). "GFP-tagged expression and immunohistochemical studies to determine the subcellular localization of the tubby gene family members.". Brain Res. Mol. Brain Res. 81 (1-2): 109–17. PMID 11000483. 
  • Santagata S, Boggon TJ, Baird CL, et al. (2001). "G-protein signaling through tubby proteins.". Science 292 (5524): 2041–50. doi:10.1126/science.1061233. PMID 11375483. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Shiri-Sverdlov R, Custers A, van Vliet-Ostaptchouk JV, et al. (2006). "Identification of TUB as a novel candidate gene influencing body weight in humans.". Diabetes 55 (2): 385–9. PMID 16443771. 
  • Giannaccini G, Giusti L, Santini F, et al. (2007). "Tubby protein in human lymphocytes from normal weight and obese subjects.". Clin. Biochem. 40 (11): 806–9. doi:10.1016/j.clinbiochem.2007.03.020. PMID 17498679. 
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