TUBB2C

From Wikipedia, the free encyclopedia

Tubulin, beta 2C

PDB rendering based on 1ffx.

Available structures: 1ffx, 1ia0, 1jff, 1sa0, 1sa1, 1tub, 1tvk, 1z2b, 2hxf, 2hxh

Identifiers

Symbol(s)

TUBB2C; TUBB2

External IDs

OMIM: 602660 MGI: 1915472 HomoloGene: 68504

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • structural molecule activity • GTP binding • MHC class I protein binding • unfolded protein binding
Cellular Component:	• cytoplasm • cytoskeleton • microtubule • protein complex
Biological Process:	• cell motility • microtubule-based movement • natural killer cell mediated cytotoxicity • protein polymerization

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006088 (mRNA)
NP_006079 (protein)

NM_146116 (mRNA)
NP_666228 (protein)

Location

Chr 9: 139.26 - 139.26 Mb

Chr 2: 25.04 - 25.05 Mb

Pubmed search

[1]

[2]

Tubulin, beta 2C, also known as TUBB2C, is a human gene.^[1]

[edit] References

^ Entrez Gene: TUBB2C tubulin, beta 2C.

[edit] Further reading

Burgoyne RD, Cambray-Deakin MA, Lewis SA, et al. (1989). "Differential distribution of beta-tubulin isotypes in cerebellum.". EMBO J. 7 (8): 2311–9. PMID 2461292.
Wang D, Villasante A, Lewis SA, Cowan NJ (1987). "The mammalian beta-tubulin repertoire: hematopoietic expression of a novel, heterologous beta-tubulin isotype.". J. Cell Biol. 103 (5): 1903–10. PMID 3782288.
Lewis SA, Gilmartin ME, Hall JL, Cowan NJ (1985). "Three expressed sequences within the human beta-tubulin multigene family each define a distinct isotype.". J. Mol. Biol. 182 (1): 11–20. PMID 3999141.
Watts NR, Sackett DL, Ward RD, et al. (2000). "HIV-1 rev depolymerizes microtubules to form stable bilayered rings.". J. Cell Biol. 150 (2): 349–60. PMID 10908577.
Szalay J, Bruno P, Bhati R, et al. (2001). "Associations of PKC isoforms with the cytoskeleton of B16F10 melanoma cells.". J. Histochem. Cytochem. 49 (1): 49–66. PMID 11118478.
Tarazona R, López-Lluch G, Galiani MD, et al. (2001). "HLA-B2702 (77-83/83-77) peptide binds to beta-tubulin on human NK cells and blocks their cytotoxic capacity.". J. Immunol. 165 (12): 6776–82. PMID 11120798.
Walss-Bass C, Xu K, David S, et al. (2003). "Occurrence of nuclear beta(II)-tubulin in cultured cells.". Cell Tissue Res. 308 (2): 215–23. doi:10.1007/s00441-002-0539-6. PMID 12037579.
Krebs DL, Uren RT, Metcalf D, et al. (2002). "SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation.". Mol. Cell. Biol. 22 (13): 4567–78. PMID 12052866.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Chen D, Wang M, Zhou S, Zhou Q (2004). "HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim.". EMBO J. 21 (24): 6801–10. PMID 12486001.
Dozier JH, Hiser L, Davis JA, et al. (2003). "Beta class II tubulin predominates in normal and tumor breast tissues.". Breast Cancer Res. 5 (5): R157–69. doi:10.1186/bcr631. PMID 12927047.
Trinczek B, Brajenovic M, Ebneth A, Drewes G (2004). "MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes.". J. Biol. Chem. 279 (7): 5915–23. doi:10.1074/jbc.M304528200. PMID 14594945.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Navarro-Lérida I, Martínez Moreno M, Roncal F, et al. (2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8.". Proteomics 4 (2): 339–46. doi:10.1002/pmic.200300528. PMID 14760703.
Campbell GR, Pasquier E, Watkins J, et al. (2005). "The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis.". J. Biol. Chem. 279 (46): 48197–204. doi:10.1074/jbc.M406195200. PMID 15331610.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
de Mareuil J, Carre M, Barbier P, et al. (2006). "HIV-1 Tat protein enhances microtubule polymerization.". Retrovirology 2: 5. doi:10.1186/1742-4690-2-5. PMID 15691386.
Giacca M (2006). "HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?". Retrovirology 2: 7. doi:10.1186/1742-4690-2-7. PMID 15698476.
Ahmed M, Forsberg J, Bergsten P (2005). "Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry.". J. Proteome Res. 4 (3): 931–40. doi:10.1021/pr050024a. PMID 15952740.