TSPAN8

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Tetraspanin 8
Identifiers
Symbol(s) TSPAN8; CO-029; TM4SF3
External IDs OMIM: 600769 MGI: 2384918 HomoloGene: 20968
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 7103 216350
Ensembl ENSG00000127324 ENSMUSG00000034127
Uniprot P19075 n/a
Refseq NM_004616 (mRNA)
NP_004607 (protein)		 NM_146010 (mRNA)
NP_666122 (protein)
Location Chr 12: 69.81 - 69.84 Mb Chr 10: 115.22 - 115.25 Mb
Pubmed search [1] [2]

Tetraspanin 8, also known as TSPAN8, is a human gene.[1]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: TSPAN8 tetraspanin 8.

[edit] Further reading

  • Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye.". J. Cell. Sci. 114 (Pt 23): 4143–51. PMID 11739647. 
  • Szala S, Kasai Y, Steplewski Z, et al. (1990). "Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens.". Proc. Natl. Acad. Sci. U.S.A. 87 (17): 6833–7. PMID 2395876. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Gwynn B, Eicher EM, Peters LL (1996). "Genetic localization of Cd63, a member of the transmembrane 4 superfamily, reveals two distinct loci in the mouse genome.". Genomics 35 (2): 389–91. doi:10.1006/geno.1996.0375. PMID 8661157. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Serru V, Le Naour F, Billard M, et al. (1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions.". Biochem. J. 340 ( Pt 1): 103–11. PMID 10229664. 
  • Kanetaka K, Sakamoto M, Yamamoto Y, et al. (2002). "Overexpression of tetraspanin CO-029 in hepatocellular carcinoma.". J. Hepatol. 35 (5): 637–42. PMID 11690710. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Shackel NA, McGuinness PH, Abbott CA, et al. (2003). "Novel differential gene expression in human cirrhosis detected by suppression subtractive hybridization.". Hepatology 38 (3): 577–88. doi:10.1053/jhep.2003.50376. PMID 12939584. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Kuhn S, Koch M, Nübel T, et al. (2007). "A complex of EpCAM, claudin-7, CD44 variant isoforms, and tetraspanins promotes colorectal cancer progression.". Mol. Cancer Res. 5 (6): 553–67. doi:10.1158/1541-7786.MCR-06-0384. PMID 17579117. 
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