TSPAN32

From Wikipedia, the free encyclopedia

Tetraspanin 32

Identifiers

TSPAN32; MGC22455; PHEMX; PHMX; TSSC6

External IDs

OMIM: 603853 MGI: 1350360 HomoloGene: 10650

Gene ontology
Molecular Function:	• molecular_function
Cellular Component:	• intracellular • membrane • integral to membrane
Biological Process:	• cell-cell signaling

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005705 (mRNA)
NP_005696 (protein)

NM_020286 (mRNA)
NP_064682 (protein)

Location

Chr 11: 2.28 - 2.3 Mb

Chr 7: 142.81 - 142.83 Mb

Pubmed search

[1]

[2]

Tetraspanin 32, also known as TSPAN32, is a human gene.^[1]

This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is located among several imprinted genes; however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4 (TSSC4), escapes imprinting. This gene may play a role in malignancies and disease that involve this region as well as hematopoietic cell function. This gene is described as a member of the tetraspanin superfamily. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.^[1]

[edit] References

^ ^a ^b Entrez Gene: TSPAN32 tetraspanin 32.

[edit] Further reading

Koi M, Johnson LA, Kalikin LM, et al. (1993). "Tumor cell growth arrest caused by subchromosomal transferable DNA fragments from chromosome 11.". Science 260 (5106): 361–4. PMID 8469989.
Hu RJ, Lee MP, Connors TD, et al. (1998). "A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes.". Genomics 46 (1): 9–17. doi:10.1006/geno.1997.4981. PMID 9403053.
Lee MP, Brandenburg S, Landes GM, et al. (1999). "Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting.". Hum. Mol. Genet. 8 (4): 683–90. PMID 10072438.
Paulsen M, El-Maarri O, Engemann S, et al. (2000). "Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse.". Hum. Mol. Genet. 9 (12): 1829–41. PMID 10915772.
Nicholson RH, Pantano S, Eliason JF, et al. (2001). "Phemx, a novel mouse gene expressed in hematopoietic cells maps to the imprinted cluster on distal chromosome 7.". Genomics 68 (1): 13–21. doi:10.1006/geno.2000.6277. PMID 10950922.
Robb L, Tarrant J, Groom J, et al. (2001). "Molecular characterisation of mouse and human TSSC6: evidence that TSSC6 is a genuine member of the tetraspanin superfamily and is expressed specifically in haematopoietic organs.". Biochim. Biophys. Acta 1522 (1): 31–41. PMID 11718897.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance.". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMID 14759258.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.