TSPAN31

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Tetraspanin 31
Identifiers
Symbol(s) TSPAN31; SAS
External IDs OMIM: 181035 MGI: 1914375 HomoloGene: 4359
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6302 67125
Ensembl ENSG00000135452 ENSMUSG00000006736
Uniprot Q12999 Q9CQ88
Refseq NM_005981 (mRNA)
NP_005972 (protein)		 NM_025982 (mRNA)
NP_080258 (protein)
Location Chr 12: 56.43 - 56.43 Mb Chr 10: 126.47 - 126.47 Mb
Pubmed search [1] [2]

Tetraspanin 31, also known as TSPAN31, is a human gene.[1]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is thought to be involved in growth-related cellular processes. This gene is associated with tumorigenesis and osteosarcoma.[1]

[edit] References

  1. ^ a b Entrez Gene: TSPAN31 tetraspanin 31.

[edit] Further reading

  • Wright MD, Tomlinson MG (1995). "The ins and outs of the transmembrane 4 superfamily.". Immunol. Today 15 (12): 588–94. PMID 7531445. 
  • Meltzer PS, Jankowski SA, Dal Cin P, et al. (1992). "Identification and cloning of a novel amplified DNA sequence in human malignant fibrous histiocytoma derived from a region of chromosome 12 frequently rearranged in soft tissue tumors.". Cell Growth Differ. 2 (10): 495–501. PMID 1661131. 
  • Jankowski SA, De Jong P, Meltzer PS (1995). "Genomic structure of SAS, a member of the transmembrane 4 superfamily amplified in human sarcomas.". Genomics 25 (2): 501–6. PMID 7789984. 
  • Jankowski SA, Mitchell DS, Smith SH, et al. (1994). "SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins.". Oncogene 9 (4): 1205–11. PMID 8134123. 
  • Elkahloun AG, Krizman DB, Wang Z, et al. (1997). "Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers.". Genomics 42 (2): 295–301. doi:10.1006/geno.1997.4727. PMID 9192850. 
  • Wunder JS, Eppert K, Burrow SR, et al. (1999). "Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas.". Oncogene 18 (3): 783–8. doi:10.1038/sj.onc.1202346. PMID 9989829. 
  • Ragazzini P, Gamberi G, Benassi MS, et al. (1999). "Analysis of SAS gene and CDK4 and MDM2 proteins in low-grade osteosarcoma.". Cancer Detect. Prev. 23 (2): 129–36. PMID 10101594. 
  • Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes.". Genome Res. 11 (5): 677–84. doi:10.1101/gr.164001. PMID 11337467. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Ragazzini P, Gamberi G, Pazzaglia L, et al. (2004). "Amplification of CDK4, MDM2, SAS and GLI genes in leiomyosarcoma, alveolar and embryonal rhabdomyosarcoma.". Histol. Histopathol. 19 (2): 401–11. PMID 15024701. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
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