TSN (gene)

From Wikipedia, the free encyclopedia

Translin

PDB rendering based on 1j1j.

Available structures: 1j1j, 1key

Identifiers

Symbol(s)

TSN; BCLF-1; REHF-1; TRSLN

External IDs

OMIM: 600575 MGI: 109263 HomoloGene: 3397

Gene ontology
Molecular Function:	• DNA binding • RNA binding • protein binding
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• DNA recombination

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004622 (mRNA)
NP_004613 (protein)

NM_011650 (mRNA)
NP_035780 (protein)

Location

Chr 2: 122.23 - 122.24 Mb

Chr 1: 120.13 - 120.14 Mb

Pubmed search

[1]

[2]

Translin, also known as TSN, is a human gene.^[1]

This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms.^[1]

[edit] References

^ ^a ^b Entrez Gene: TSN translin.

[edit] Further reading

Aoki K, Suzuki K, Sugano T, et al. (1995). "A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations.". Nat. Genet. 10 (2): 167-74. doi:10.1038/ng0695-167. PMID 7663511.
Kasai M, Aoki K, Matsuo Y, et al. (1994). "Recombination hotspot associated factors specifically recognize novel target sequences at the site of interchromosomal rearrangements in T-ALL patients with t(8;14)(q24;q11) and t(1;14)(p32;q11).". Int. Immunol. 6 (7): 1017-25. PMID 7947454.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Aoki K, Nakahara K, Ikegawa C, et al. (1994). "Nuclear proteins binding to a novel target sequence within the recombination hotspot regions of Bcl-2 and the immunoglobulin DH gene family.". Oncogene 9 (4): 1109-15. PMID 8134113.
Aoki K, Ishida R, Kasai M (1997). "Isolation and characterization of a cDNA encoding a Translin-like protein, TRAX.". FEBS Lett. 401 (2-3): 109-12. PMID 9013868.
Kasai M, Matsuzaki T, Katayanagi K, et al. (1997). "The translin ring specifically recognizes DNA ends at recombination hot spots in the human genome.". J. Biol. Chem. 272 (17): 11402-7. PMID 9111049.
Aoki K, Inazawa J, Takahashi T, et al. (1997). "Genomic structure and chromosomal localization of the gene encoding translin, a recombination hotspot binding protein.". Genomics 43 (2): 237-41. doi:10.1006/geno.1997.4796. PMID 9244443.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Hasegawa T, Isobe K (1999). "Evidence for the interaction between Translin and GADD34 in mammalian cells.". Biochim. Biophys. Acta 1428 (2-3): 161-8. PMID 10434033.
Badge RM, Yardley J, Jeffreys AJ, Armour JA (2000). "Crossover breakpoint mapping identifies a subtelomeric hotspot for male meiotic recombination.". Hum. Mol. Genet. 9 (8): 1239-44. PMID 10767349.
Hosaka T, Kanoe H, Nakayama T, et al. (2001). "Translin binds to the sequences adjacent to the breakpoints of the TLS and CHOP genes in liposarcomas with translocation t(12;6).". Oncogene 19 (50): 5821-5. doi:10.1038/sj.onc.1203943. PMID 11126370.
Chennathukuzhi VM, Kurihara Y, Bray JD, Hecht NB (2001). "Trax (translin-associated factor X), a primarily cytoplasmic protein, inhibits the binding of TB-RBP (translin) to RNA.". J. Biol. Chem. 276 (16): 13256-63. doi:10.1074/jbc.M009707200. PMID 11278549.
Lee SP, Fuior E, Lewis MS, Han MK (2001). "Analytical ultracentrifugation studies of translin: analysis of protein-DNA interactions using a single-stranded fluorogenic oligonucleotide.". Biochemistry 40 (46): 14081-8. PMID 11705401.
Erdemir T, Bilican B, Oncel D, et al. (2002). "DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX).". J. Cell. Sci. 115 (Pt 1): 207-16. PMID 11801738.
Han MK, Lin P, Paek D, et al. (2002). "Fluorescence studies of pyrene maleimide-labeled translin: excimer fluorescence indicates subunits associate in a tail-to-tail configuration to form octamer.". Biochemistry 41 (10): 3468-76. PMID 11876655.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Sengupta K, Rao BJ (2003). "Translin binding to DNA: recruitment through DNA ends and consequent conformational transitions.". Biochemistry 41 (51): 15315-26. PMID 12484770.
Li K, Wang L, Cheng J, et al. (2003). "Interaction between hepatitis C virus core protein and translin protein--a possible molecular mechanism for hepatocellular carcinoma and lymphoma caused by hepatitis C virus.". World J. Gastroenterol. 9 (2): 300-3. PMID 12532453.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Yang S, Cho YS, Chennathukuzhi VM, et al. (2004). "Translin-associated factor X is post-transcriptionally regulated by its partner protein TB-RBP, and both are essential for normal cell proliferation.". J. Biol. Chem. 279 (13): 12605-14. doi:10.1074/jbc.M313133200. PMID 14711818.