TSNAX

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Translin-associated factor X
Identifiers
Symbol(s) TSNAX; TRAX
External IDs OMIM: 602964 MGI: 1855672 HomoloGene: 4374
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 7257 53424
Ensembl ENSG00000116918 n/a
Uniprot Q99598 n/a
Refseq NM_005999 (mRNA)
NP_005990 (protein)		 XM_001002375 (mRNA)
XP_001002375 (protein)
Location Chr 1: 229.73 - 229.77 Mb n/a
Pubmed search [1] [2]

Translin-associated factor X, also known as TSNAX, is a human gene.[1]

This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs.[1]

[edit] References

  1. ^ a b Entrez Gene: TSNAX translin-associated factor X.

[edit] Further reading

  • Aoki K, Ishida R, Kasai M (1997). "Isolation and characterization of a cDNA encoding a Translin-like protein, TRAX.". FEBS Lett. 401 (2-3): 109-12. PMID 9013868. 
  • Millar JK, Christie S, Semple CA, Porteous DJ (2001). "Chromosomal location and genomic structure of the human translin-associated factor X gene (TRAX; TSNAX) revealed by intergenic splicing to DISC1, a gene disrupted by a translocation segregating with schizophrenia.". Genomics 67 (1): 69-77. doi:10.1006/geno.2000.6239. PMID 10945471. 
  • Meng G, Aoki K, Tokura K, et al. (2000). "Genomic structure and chromosomal localization of the gene encoding TRAX, a Translin-associated factor X.". J. Hum. Genet. 45 (5): 305-8. PMID 11043515. 
  • Chennathukuzhi VM, Kurihara Y, Bray JD, Hecht NB (2001). "Trax (translin-associated factor X), a primarily cytoplasmic protein, inhibits the binding of TB-RBP (translin) to RNA.". J. Biol. Chem. 276 (16): 13256-63. doi:10.1074/jbc.M009707200. PMID 11278549. 
  • Erdemir T, Bilican B, Oncel D, et al. (2002). "DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX).". J. Cell. Sci. 115 (Pt 1): 207-16. PMID 11801738. 
  • Bray JD, Chennathukuzhi VM, Hecht NB (2002). "Identification and characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X.". Genomics 79 (6): 799-808. doi:10.1006/geno.2002.6779. PMID 12036294. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Wu RF, Osatomi K, Terada LS, Uyeda K (2004). "Identification of Translin/Trax complex as a glucose response element binding protein in liver.". Biochim. Biophys. Acta 1624 (1-3): 29-35. PMID 14642810. 
  • Yang S, Cho YS, Chennathukuzhi VM, et al. (2004). "Translin-associated factor X is post-transcriptionally regulated by its partner protein TB-RBP, and both are essential for normal cell proliferation.". J. Biol. Chem. 279 (13): 12605-14. doi:10.1074/jbc.M313133200. PMID 14711818. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Gocke CB, Yu H, Kang J (2005). "Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates.". J. Biol. Chem. 280 (6): 5004-12. doi:10.1074/jbc.M411718200. PMID 15561718. 
  • Thomson PA, Wray NR, Millar JK, et al. (2005). "Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population.". Mol. Psychiatry 10 (7): 657-68, 616. doi:10.1038/sj.mp.4001669. PMID 15838535. 
  • Gupta GD, Makde RD, Kamdar RP, et al. (2005). "Co-expressed recombinant human Translin-Trax complex binds DNA.". FEBS Lett. 579 (14): 3141-6. doi:10.1016/j.febslet.2005.05.007. PMID 15919079. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
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