TSLP

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Thymic stromal lymphopoietin
Identifiers
Symbol(s) TSLP;
External IDs OMIM: 607003 MGI: 1855696 HomoloGene: 81957
Orthologs
Human Mouse
Entrez 85480 53603
Ensembl ENSG00000145777 ENSMUSG00000024379
Refseq NM_033035 (mRNA)
NP_149024 (protein)		 NM_021367 (mRNA)
NP_067342 (protein)
Location Chr 5: 110.43 - 110.44 Mb Chr 18: 32.96 - 32.96 Mb
Pubmed search [1] [2]

Thymic stromal lymphopoietin, also known as TSLP, is a human gene.[1]

This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. Alternative splicing of this gene results in two transcript variants.[1]

[edit] References

  1. ^ a b Entrez Gene: TSLP thymic stromal lymphopoietin.

[edit] Further reading

  • Soumelis V, Liu YJ (2004). "Human thymic stromal lymphopoietin: a novel epithelial cell-derived cytokine and a potential key player in the induction of allergic inflammation.". Springer Semin. Immunopathol. 25 (3-4): 325-33. doi:10.1007/s00281-003-0152-0. PMID 14999427. 
  • Ziegler SF, Liu YJ (2006). "Thymic stromal lymphopoietin in normal and pathogenic T cell development and function.". Nat. Immunol. 7 (7): 709-14. doi:10.1038/ni1360. PMID 16785889. 
  • Liu YJ (2007). "Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell-mediated allergic inflammation.". J. Allergy Clin. Immunol. 120 (2): 238-44; quiz 245-6. doi:10.1016/j.jaci.2007.06.004. PMID 17666213. 
  • Isaksen DE, Baumann H, Trobridge PA, et al. (1999). "Requirement for stat5 in thymic stromal lymphopoietin-mediated signal transduction.". J. Immunol. 163 (11): 5971-7. PMID 10570284. 
  • Reche PA, Soumelis V, Gorman DM, et al. (2001). "Human thymic stromal lymphopoietin preferentially stimulates myeloid cells.". J. Immunol. 167 (1): 336-43. PMID 11418668. 
  • Quentmeier H, Drexler HG, Fleckenstein D, et al. (2001). "Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation.". Leukemia 15 (8): 1286-92. PMID 11480573. 
  • Soumelis V, Reche PA, Kanzler H, et al. (2002). "Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP.". Nat. Immunol. 3 (7): 673-80. doi:10.1038/ni805. PMID 12055625. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gilliet M, Soumelis V, Watanabe N, et al. (2003). "Human dendritic cells activated by TSLP and CD40L induce proallergic cytotoxic T cells.". J. Exp. Med. 197 (8): 1059-63. doi:10.1084/jem.20030240. PMID 12707303. 
  • Watanabe N, Hanabuchi S, Marloie-Provost MA, et al. (2005). "Human TSLP promotes CD40 ligand-induced IL-12 production by myeloid dendritic cells but maintains their Th2 priming potential.". Blood 105 (12): 4749-51. doi:10.1182/blood-2004-09-3622. PMID 15741223. 
  • Ying S, O'Connor B, Ratoff J, et al. (2005). "Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity.". J. Immunol. 174 (12): 8183-90. PMID 15944327. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
  • Lee HC, Ziegler SF (2007). "Inducible expression of the proallergic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NFkappaB.". Proc. Natl. Acad. Sci. U.S.A. 104 (3): 914-9. doi:10.1073/pnas.0607305104. PMID 17213320. 
  • Ebner S, Nguyen VA, Forstner M, et al. (2007). "Thymic stromal lymphopoietin converts human epidermal Langerhans cells into antigen-presenting cells that induce proallergic T cells.". J. Allergy Clin. Immunol. 119 (4): 982-90. doi:10.1016/j.jaci.2007.01.003. PMID 17320941. 
  • Koyama K, Ozawa T, Hatsushika K, et al. (2007). "A possible role for TSLP in inflammatory arthritis.". Biochem. Biophys. Res. Commun. 357 (1): 99-104. doi:10.1016/j.bbrc.2007.03.081. PMID 17416344. 
  • Zhang K, Shan L, Rahman MS, et al. (2007). "Constitutive and inducible thymic stromal lymphopoietin expression in human airway smooth muscle cells: role in chronic obstructive pulmonary disease.". Am. J. Physiol. Lung Cell Mol. Physiol. 293 (2): L375-82. doi:10.1152/ajplung.00045.2007. PMID 17513456. 
  • Rochman I, Watanabe N, Arima K, et al. (2007). "Cutting edge: direct action of thymic stromal lymphopoietin on activated human CD4+ T cells.". J. Immunol. 178 (11): 6720-4. PMID 17513717. 
  • Wang YH, Angkasekwinai P, Lu N, et al. (2007). "IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells.". J. Exp. Med. 204 (8): 1837-47. doi:10.1084/jem.20070406. PMID 17635955. 
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