TSEN2

From Wikipedia, the free encyclopedia


TRNA splicing endonuclease 2 homolog (S. cerevisiae)
Identifiers
Symbol(s) TSEN2; SEN2; MGC2776; MGC4440; SEN2L
External IDs OMIM: 608753 MGI2141599 HomoloGene41622
RNA expression pattern

More reference expression data

Orthologs
Human Mouse
Entrez 80746 381802
Ensembl ENSG00000154743 ENSMUSG00000042389
Uniprot Q8NCE0 Q6P7W5
Refseq NM_025265 (mRNA)
NP_079541 (protein)
NM_199033 (mRNA)
NP_950198 (protein)
Location Chr 3: 12.5 - 12.56 Mb Chr 6: 115.51 - 115.54 Mb
Pubmed search [1] [2]

TRNA splicing endonuclease 2 homolog (S. cerevisiae), also known as TSEN2, is a human gene.[1]

tRNA splicing is a fundamental process required for cell growth and division. SEN2 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al., 2004).[supplied by OMIM][1]

[edit] References

[edit] Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093-101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747. 
  • Paushkin SV, Patel M, Furia BS, et al. (2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation.". Cell 117 (3): 311-21. PMID 15109492. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773-84. doi:10.1101/gr.406902. PMID 12421765. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.