TSC22D1

From Wikipedia, the free encyclopedia

TSC22 domain family, member 1

Identifiers

TSC22D1; DKFZp686O19206; MGC17597; RP11-269C23.2; TGFB1I4; TSC22

External IDs

OMIM: 607715 MGI: 109127 HomoloGene: 7573

Gene ontology
Molecular Function:	• transcription factor activity
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006022 (mRNA)
NP_006013 (protein)

NM_009366 (mRNA)
NP_033392 (protein)

Location

Chr 13: 43.91 - 44.05 Mb

Chr 14: 75.15 - 75.24 Mb

Pubmed search

[1]

[2]

TSC22 domain family, member 1, also known as TSC22D1, is a human gene.^[1]

TSC22 encodes a transcription factor and belongs to the large family of early response genes.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: TSC22D1 TSC22 domain family, member 1.

[edit] Further reading

Shibanuma M, Kuroki T, Nose K (1992). "Isolation of a gene encoding a putative leucine zipper structure that is induced by transforming growth factor beta 1 and other growth factors.". J. Biol. Chem. 267 (15): 10219–24. PMID 1587811.
Jay P, Ji JW, Marsollier C, et al. (1996). "Cloning of the human homologue of the TGF beta-stimulated clone 22 gene.". Biochem. Biophys. Res. Commun. 222 (3): 821–6. doi:10.1006/bbrc.1996.0825. PMID 8651929.
Ohta S, Shimekake Y, Nagata K (1997). "Molecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter.". Eur. J. Biochem. 242 (3): 460–6. PMID 9022669.
Dmitrenko VV, Garifulin OM, Shostak EA, et al. (1997). "[The characteristics of different types of mRNA expressed in the human brain]". Tsitol. Genet. 30 (5): 41–7. PMID 9026990.
Kester HA, Blanchetot C, den Hertog J, et al. (1999). "Transforming growth factor-beta-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity.". J. Biol. Chem. 274 (39): 27439–47. PMID 10488076.
Hino S, Kawamata H, Uchida D, et al. (2001). "Nuclear translocation of TSC-22 (TGF-beta-stimulated clone-22) concomitant with apoptosis: TSC-22 as a putative transcriptional regulator.". Biochem. Biophys. Res. Commun. 278 (3): 659–64. doi:10.1006/bbrc.2000.3840. PMID 11095965.
Hino S, Kawamata H, Omotehara F, et al. (2002). "Leucine zipper structure of TSC-22 (TGF-beta stimulated clone-22) markedly inhibits the anchorage-independent growth of salivary gland cancer cells.". Oncol. Rep. 9 (2): 371–4. PMID 11836610.
Hino S, Kawamata H, Omotehara F, et al. (2002). "Cytoplasmic TSC-22 (transforming growth factor-beta-stimulated clone-22) markedly enhances the radiation sensitivity of salivary gland cancer cells.". Biochem. Biophys. Res. Commun. 292 (4): 957–63. doi:10.1006/bbrc.2002.6776. PMID 11944908.
Ohara O, Nagase T, Mitsui G, et al. (2003). "Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method.". DNA Res. 9 (2): 47–57. PMID 12056414.
Gupta RA, Sarraf P, Brockman JA, et al. (2003). "Peroxisome proliferator-activated receptor gamma and transforming growth factor-beta pathways inhibit intestinal epithelial cell growth by regulating levels of TSC-22.". J. Biol. Chem. 278 (9): 7431–8. doi:10.1074/jbc.M208076200. PMID 12468551.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Sugawara F, Yamada Y, Watanabe R, et al. (2004). "The role of the TSC-22 (-396) A/G variant in the development of diabetic nephropathy.". Diabetes Res. Clin. Pract. 60 (3): 191–7. PMID 12757981.
Uchida D, Omotehara F, Nakashiro K, et al. (2003). "Posttranscriptional regulation of TSC-22 (TGF-beta-stimulated clone-22) gene by TGF-beta 1.". Biochem. Biophys. Res. Commun. 305 (4): 846–54. PMID 12767908.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Choi SJ, Moon JH, Ahn YW, et al. (2005). "Tsc-22 enhances TGF-beta signaling by associating with Smad4 and induces erythroid cell differentiation.". Mol. Cell. Biochem. 271 (1-2): 23–8. PMID 15881652.
Rentsch CA, Cecchini MG, Schwaninger R, et al. (2006). "Differential expression of TGFbeta-stimulated clone 22 in normal prostate and prostate cancer.". Int. J. Cancer 118 (4): 899–906. doi:10.1002/ijc.21449. PMID 16106424.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Lu Y, Kitaura J, Oki T, et al. (2007). "Identification of TSC-22 as a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD.". Leukemia 21 (11): 2246–57. doi:10.1038/sj.leu.2404883. PMID 17690703.