Tryptophan repressor

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Tryptophan repressor is a transcription factor involved in controlling amino acid metabolism. It has been best studies in Escherichia coli, where it is a dimeric protein that regulates transcription of the 5 genes in the tryptophan operon.[1] When the amino acid tryptophan is plentiful in the cell, it binds to the protein, which causes a conformational change in the protein.[2] The repressor complex then binds to its operator sequence in the 5 genes it regulates, shutting off the genes.[3][4]

One of these genes, trpR, codes for the production of tryptophan itself. Another codes for the tryptophan repressor protein. These are forms of feedback regulation.


[edit] See also

[edit] References

  1. ^ Santillan M, Mackey MC (2001). "Dynamic regulation of the tryptophan operon: a modeling study and comparison with experimental data". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1364–9. PMID 11171956. 
  2. ^ Zhang RG, Joachimiak A, Lawson CL, Schevitz RW, Otwinowski Z, Sigler PB (1987). "The crystal structure of trp aporepressor at 1.8 A shows how binding tryptophan enhances DNA affinity". Nature 327 (6123): 591–7. PMID 3600756. 
  3. ^ Jeeves M, Evans PD, Parslow RA, Jaseja M, Hyde EI (1999). "Studies of the Escherichia coli Trp repressor binding to its five operators and to variant operator sequences". Eur. J. Biochem. 265 (3): 919–28. PMID 10518785. 
  4. ^ Arvidson DN, Arvidson CG, Lawson CL, Miner J, Adams C, Youderian P (1994). "The tryptophan repressor sequence is highly conserved among the Enterobacteriaceae". Nucleic Acids Res. 22 (10): 1821–9. PMID 8208606. 


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