Tryptophan dimethylallyltransferase

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In enzymology, a tryptophan dimethylallyltransferase (EC 2.5.1.34) is an enzyme that catalyzes the chemical reaction

dimethylallyl diphosphate + L-tryptophan $\rightleftharpoons$ diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan

Thus, the two substrates of this enzyme are dimethylallyl diphosphate and L-tryptophan, whereas its two products are diphosphate and 4-(3-methylbut-2-enyl)-L-tryptophan.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is dimethylallyl-diphosphate:L-tryptophan dimethylallyltransferase. Other names in common use include dimethylallylpyrophosphate:L-tryptophan dimethylallyltransferase, dimethylallyltryptophan synthetase, dimethylallylpyrophosphate:tryptophan dimethylallyl transferase, DMAT synthetase, and 4-(gamma,gamma-dimethylallyl)tryptophan synthase.

[edit] References

IUBMB entry for 2.5.1.34
BRENDA references for 2.5.1.34 (Recommended.)
PubMed references for 2.5.1.34
PubMed Central references for 2.5.1.34
Google Scholar references for 2.5.1.34
Lee SL, Floss HG, Heinstein P (1976). "Purification and properties of dimethylallylpyrophosphate:tryptopharm dimethylallyl transferase, the first enzyme of ergot alkaloid biosynthesis in Claviceps. sp. SD 58". Arch. Biochem. Biophys. 177: 84–94. PMID 999297.