Tryptophan dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a tryptophan dehydrogenase (EC 1.4.1.19) is an enzyme that catalyzes the chemical reaction

L-tryptophan + NAD(P)+ + H₂O (indol-3-yl)pyruvate + NH₃ + NAD(P)H + H⁺

The 4 substrates of this enzyme are L-tryptophan, NAD⁺, NADP⁺, and H₂O, whereas its 5 products are (indol-3-yl)pyruvate, NH₃, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-tryptophan:NAD(P)+ oxidoreductase (deaminating). Other names in common use include NAD(P)+-L-tryptophan dehydrogenase, L-tryptophan dehydrogenase, L-Trp-dehydrogenase, and TDH. This enzyme has at least one effector, calcium.

[edit] References

• IUBMB entry for 1.4.1.19
• BRENDA references for 1.4.1.19 (Recommended.)
• PubMed references for 1.4.1.19
• PubMed Central references for 1.4.1.19
• Google Scholar references for 1.4.1.19
• Vackova K, Mehta A and Kutacek M (1985). "Tryptophan aminotransferase and tryptophan dehydrogenase - activities in some cell compartments of spinach leaves - the effect of calcium-ions on tryptophan dehydrogenase". Biol. Plant. 27: 154–158. doi:10.1007/BF02902153. 

[edit] External links

The CAS registry number for this enzyme class is 94047-13-9.

• IUBMB entry for 1.4.1.19

• KEGG entry for 1.4.1.19

• BRENDA entry for 1.4.1.19

• NiceZyme view of 1.4.1.19

• EC2PDB: PDB structures for 1.4.1.19

• PRIAM entry for 1.4.1.19

• PUMA2 entry for 1.4.1.19

• IntEnz: Integrated Enzyme entry for 1.4.1.19

• MetaCyc entry for 1.4.1.19

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050363: tryptophan dehydrogenase

• AMIGO entry for GO code 0050363: tryptophan dehydrogenase