Tryptophan alpha,beta-oxidase

From Wikipedia, the free encyclopedia

In enzymology, a tryptophan alpha,beta-oxidase (EC 1.3.3.10) is an enzyme that catalyzes the chemical reaction

L-tryptophan + O₂ alpha,beta-didehydrotryptophan + H₂O₂

Thus, the two substrates of this enzyme are L-tryptophan and O₂, whereas its two products are alpha,beta-didehydrotryptophan and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with oxygen as acceptor. The systematic name of this enzyme class is L-tryptophan:oxygen alpha,beta-oxidoreductase. Other names in common use include L-tryptophan 2',3'-oxidase, and L-tryptophan alpha,beta-dehydrogenase. It employs one cofactor, heme.

[edit] References

• IUBMB entry for 1.3.3.10
• BRENDA references for 1.3.3.10 (Recommended.)
• PubMed references for 1.3.3.10
• PubMed Central references for 1.3.3.10
• Google Scholar references for 1.3.3.10
• Genet R, Denoyelle C, Menez A (1994). "Purification and partial characterization of an amino acid alpha,beta- dehydrogenase, L-tryptophan 2',3'-oxidase from Chromobacterium violaceum". J. Biol. Chem. 269: 18177–84. PMID 8027079. 
• Genet R, Benetti PH, Hammadi A, Menez A (1995). "L-tryptophan 2',3'-oxidase from Chromobacterium violaceum. Substrate specificity and mechanistic implications". J. Biol. Chem. 270: 23540–5. PMID 7559518. 

[edit] External links

The CAS registry number for this enzyme class is 156859-19-7.

• IUBMB entry for 1.3.3.10

• KEGG entry for 1.3.3.10

• BRENDA entry for 1.3.3.10

• NiceZyme view of 1.3.3.10

• EC2PDB: PDB structures for 1.3.3.10

• PRIAM entry for 1.3.3.10

• PUMA2 entry for 1.3.3.10

• IntEnz: Integrated Enzyme entry for 1.3.3.10

• MetaCyc entry for 1.3.3.10

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050621: tryptophan alpha,beta-oxidase

• AMIGO entry for GO code 0050621: tryptophan alpha,beta-oxidase