Tryptophan 2-monooxygenase

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In enzymology, a tryptophan 2-monooxygenase (EC 1.13.12.3) is an enzyme that catalyzes the chemical reaction

L-tryptophan + O₂ $\rightleftharpoons$ (indol-3-yl)acetamide + CO₂ + H₂O

Thus, the two substrates of this enzyme are L-tryptophan and O₂, whereas its 3 products are (indol-3-yl)acetamide, CO₂, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O with incorporation of one atom of oxygen (internal monooxygenases o internal mixed-function oxidases). The systematic name of this enzyme class is L-tryptophan:oxygen 2-oxidoreductase (decarboxylating). This enzyme participates in tryptophan metabolism.

[edit] References

IUBMB entry for 1.13.12.3
BRENDA references for 1.13.12.3 (Recommended.)
PubMed references for 1.13.12.3
PubMed Central references for 1.13.12.3
Google Scholar references for 1.13.12.3
Kosuge T, Heskett MG, Wilson EE (1966). "Microbial synthesis and degradation of indole-3-acetic acid. I. The conversion of L-tryptophan to indole-3-acetamide by an enzyme system from Pseudomonas savastanoi". J. Biol. Chem. 241: 3738–44. PMID 5916389.
Kuo, TT and Kosuge T (1969). "Factors influencing the production and further metabolism of indole-3-acetic acid by Pseudomonas savastanoi". J. Gen. Appl. Microbiol. 15: 51–63. doi:10.2323/jgam.15.51.