Tryptophan 2'-dioxygenase

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In enzymology, a tryptophan 2'-dioxygenase (EC 1.13.99.3) is an enzyme that catalyzes the chemical reaction

L-tryptophan + O₂ $\rightleftharpoons$ (indol-3-yl)glycolaldehyde + CO₂ + NH₃

Thus, the two substrates of this enzyme are L-tryptophan and O₂, whereas its 3 products are (indol-3-yl)glycolaldehyde, CO₂, and NH₃.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O miscellaneous. The systematic name of this enzyme class is L-tryptophan:oxygen 2'-oxidoreductase (side-chain-cleaving). Other names in common use include indole-3-alkane alpha-hydroxylase, tryptophan side-chain alpha,beta-oxidase, tryptophan side chain oxidase II, tryptophan side-chain oxidase, TSO, indolyl-3-alkan alpha-hydroxylase, tryptophan side chain oxidase type I, TSO I, TSO II, and tryptophan side chain oxidase. This enzyme participates in tryptophan metabolism. It employs one cofactor, heme.

[edit] References

IUBMB entry for 1.13.99.3
BRENDA references for 1.13.99.3 (Recommended.)
PubMed references for 1.13.99.3
PubMed Central references for 1.13.99.3
Google Scholar references for 1.13.99.3
Roberts J, Rosenfeld HJ (1977). "Isolation, crystallization, and properties of indolyl-3-alkane alpha-hydroxylase. A novel tryptophan-metabolizing enzyme". J. Biol. Chem. 252: 2640–7. PMID 15994.
Takai K, Ushiro H, Noda Y, Narumiya S, Tokuyama T (1977). "Crystalline hemoprotein from Pseudomonas that catalyzes oxidation of side chain of tryptophan and other indole derivatives". J. Biol. Chem. 252: 2648–56. PMID 15995.