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Trypsin inhibitors are chemicals that reduce the availability of trypsin, an enzyme essential to nutrition of many animals, including humans.
There are four commercial sources of trypsin inhibitors.
| Source |
Molecular weight |
Inhibitatory power |
Details |
| Serum (α1-antitrypsin) |
52 kDa |
|
Also known as serum trypsin inhibitor |
| Lima beans |
8-10 kDa |
2.2 times weight |
There are six different lima bean inhibitors. |
| Bovine pancreas |
6.5 kDa |
2.5 times weight |
Kunitz inhibitor is the best known pancreatic inhibitor. Chymotrypsin is also inhibited by this chemical, but less tightly. When extracted from lung tissue, this is known as aprotinin. |
| Ovomucoid |
8-10 kDa |
1.2 times weight |
Ovomucoids are the glycoprotein protease inhibitors found in avian egg white. There are other protease inhibitors in ovomucoids as well. |
| Soybeans |
20.7-22.3 kDa |
1.2 times weight |
Soybeans contain several inhibitors; the one in the chart is considered the primary one. All of them bind chymotryptin to a lesser degree. |
[edit] See also
[edit] References
- Jones et al., Biochem., 2, 66, (1963)
- Lineweaver and Murray JBC, 171, 565 (1947)
- Kunitz and Northrop J. Gen. Physiol., 19, 991 (1936)
- Fraenkel-Conrat, et al., Arch. Biochem. Biophys., 37, 393 (1952)
- Frattali, V., and Steiner, R.: Biochem., 7, 521 (1968)
[edit] External links
