Trypanothione synthase

From Wikipedia, the free encyclopedia

In enzymology, a trypanothione synthase (EC 6.3.1.9) is an enzyme that catalyzes the chemical reaction

glutathione + glutathionylspermidine + ATP N₁,N₈-bis(glutathionyl)spermidine + ADP + phosphate

The 3 substrates of this enzyme are glutathione, glutathionylspermidine, and ATP, whereas its 3 products are N1,N8-bis(glutathionyl)spermidine, ADP, and phosphate.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-ammonia (or amine) ligases (amide synthases). The systematic name of this enzyme class is glutathionylspermidine:glutathione ligase (ADP-forming).

[edit] References

• IUBMB entry for 6.3.1.9
• BRENDA references for 6.3.1.9 (Recommended.)
• PubMed references for 6.3.1.9
• PubMed Central references for 6.3.1.9
• Google Scholar references for 6.3.1.9
• Smith K, Nadeau K, Bradley M, Walsh C, Fairlamb AH (1992). "Purification of glutathionylspermidine and trypanothione synthetases from Crithidia fasciculata". Protein. Sci. 1: 874–83. PMID 1304372. 

[edit] External links

The CAS registry number for this enzyme class is 130246-69-4.

• IUBMB entry for 6.3.1.9

• KEGG entry for 6.3.1.9

• BRENDA entry for 6.3.1.9

• NiceZyme view of 6.3.1.9

• EC2PDB: PDB structures for 6.3.1.9

• PRIAM entry for 6.3.1.9

• PUMA2 entry for 6.3.1.9

• IntEnz: Integrated Enzyme entry for 6.3.1.9

• MetaCyc entry for 6.3.1.9

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047479: trypanothione synthase

• AMIGO entry for GO code 0047479: trypanothione synthase