TRPV5

From Wikipedia, the free encyclopedia

Transient receptor potential cation channel, subfamily V, member 5

Identifiers

TRPV5; CAT2; ECAC1; OTRPC3

External IDs

OMIM: 606679 MGI: 2429764 HomoloGene: 10520

Gene ontology
Molecular Function:	• ion channel activity • calcium channel activity • calcium ion binding • protein binding
Cellular Component:	• integral to plasma membrane • membrane • apical plasma membrane
Biological Process:	• ion transport • calcium ion transport • cellular calcium ion homeostasis • protein tetramerization

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_019841 (mRNA)
NP_062815 (protein)

NM_001007572 (mRNA)
NP_001007573 (protein)

Location

Chr 7: 142.32 - 142.34 Mb

Chr 6: 41.58 - 41.61 Mb

Pubmed search

[1]

[2]

Transient receptor potential cation channel, subfamily V, member 5, also known as TRPV5, is a human gene.

This gene is a member of the transient receptor family and the TRPV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level.^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

TRPV

[edit] References

^ Entrez Gene: TRPV5 transient receptor potential cation channel, subfamily V, member 5.

[edit] Further reading

Vennekens R, Droogmans G, Nilius B (2002). "Functional properties of the epithelial Ca2+ channel, ECaC.". Gen. Physiol. Biophys. 20 (3): 239–53. PMID 11765215.
Heiner I, Eisfeld J, Lückhoff A (2004). "Role and regulation of TRP channels in neutrophil granulocytes.". Cell Calcium 33 (5-6): 533–40. PMID 12765698.
Nijenhuis T, Hoenderop JG, Bindels RJ (2006). "TRPV5 and TRPV6 in Ca(2+) (re)absorption: regulating Ca(2+) entry at the gate.". Pflugers Arch. 451 (1): 181–92. doi:10.1007/s00424-005-1430-6. PMID 16044309.
Clapham DE, Julius D, Montell C, Schultz G (2006). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100.
Mensenkamp AR, Hoenderop JG, Bindels RJ (2007). "TRPV5, the gateway to Ca2+ homeostasis.". Handb Exp Pharmacol (179): 207–20. doi:10.1007/978-3-540-34891-7_12. PMID 17217059.
Schoeber JP, Hoenderop JG, Bindels RJ (2007). "Concerted action of associated proteins in the regulation of TRPV5 and TRPV6.". Biochem. Soc. Trans. 35 (Pt 1): 115–9. doi:10.1042/BST0350115. PMID 17233615.

[edit] External links

MeSH TRPV5+protein,+human

This membrane protein-related article is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e Membrane transport protein: ion channels

Ca²⁺: Calcium channel	Voltage-dependent calcium channel (L-type/Ca_vα(1.1, 1.2, 1.3, 1.4), N-type, P-type/Ca_vα(2.1), Q-type, R-type, T-type, α₂δ-subunits (1, 2), β-subunits (β1, β2, β3, β4), γ-subunits (γ1, γ2, γ3, γ4) Inositol triphosphate receptor • Ryanodine receptor • Cation channels of sperm • Two-pore channel

Na⁺: Sodium channel	Na_vα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.9, 7A) • Na_vβ (1, 2, 3, 4) • Epithelial sodium channel

K⁺: Potassium channel	Voltage-gated (K_vα (1.1, 1.2, 1.3, 1.4, 1.5, 2.1, 3.1, 3.4, 4.1, 4.2, 4.3, 6.1, 7.1, 7.2, 7.3, 7.4, 7.5, 9.3, 10.1, 11.1/hERG) • K_vβ (1, 2), Shaker gene, KCNE1) Calcium-activated (BK channel: α1, β1, β2, β3, β4; SK channel: SK1, SK2, SK3, SK4) Inward-rectifier K_ir (1.1, 2.1, 2.2, 2.3, 2.4, GIRK, 3.1, 3.2, 3.3, 3.4, 4.1, 4.2, 5.1, 6.1, 6.2, 7.1) Tandem pore domain K2P (1, 2, 3, 4, 6, 9, 15, 17)

Cl^-: Chloride channel	Cystic fibrosis transmembrane conductance regulator

Porin	Aquaporin (1, 2, 3, 4, 5, 7, 8, 9) • Voltage-dependent anion channel (1)

Cations: TRP	TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (Mucolipin-1) • TRPP (1, 2) • TRPV (1, 2, 3, 4, 5, 6)

Other/general	Voltage-gated ion channel • Ligand-gated ion channel • Cyclic nucleotide-gated ion channel (α1, α2, α3, β1, β3, H1, H2, H3, H4) • Stretch-activated ion channel