TRPV4

From Wikipedia, the free encyclopedia

Transient receptor potential cation channel, subfamily V, member 4

Identifiers

TRPV4; OTRPC4; TRP12; VR-OAC; VRL-2; VRL2; VROAC

External IDs

OMIM: 605427 MGI: 1926945 HomoloGene: 11003

Gene ontology
Molecular Function:	• receptor activity • osmosensor activity • ion channel activity • calcium channel activity • calcium ion binding • calmodulin binding • cation channel activity • identical protein binding
Cellular Component:	• plasma membrane • membrane • integral to membrane
Biological Process:	• ion transport • calcium ion transport • cellular calcium ion homeostasis • regulation of cell volume • osmosensory signaling pathway • response to mechanical stimulus • vasopressin secretion • hyperosmotic salinity response • regulation of response to osmotic stress

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_021625 (mRNA)
NP_067638 (protein)

NM_022017 (mRNA)
NP_071300 (protein)

Location

Chr 12: 108.71 - 108.76 Mb

Chr 5: 114.88 - 114.92 Mb

Pubmed search

[1]

[2]

Transient receptor potential cation channel, subfamily V, member 4, also known as TRPV4, is a human gene.

This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Two transcript variants encoding different isoforms have been found for this gene.^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

TRPV

[edit] References

^ Entrez Gene: TRPV4 transient receptor potential cation channel, subfamily V, member 4.

[edit] Further reading

Harteneck C, Plant TD, Schultz G (2000). "From worm to man: three subfamilies of TRP channels.". Trends Neurosci. 23 (4): 159–66. PMID 10717675.
Clapham DE, Julius D, Montell C, Schultz G (2006). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100.
Plant TD, Strotmann R (2007). "TRPV4.". Handb Exp Pharmacol (179): 189–205. doi:10.1007/978-3-540-34891-7_11. PMID 17217058.
Harteneck C, Reiter B (2007). "TRP channels activated by extracellular hypo-osmoticity in epithelia.". Biochem. Soc. Trans. 35 (Pt 1): 91–5. doi:10.1042/BST0350091. PMID 17233610.

[edit] External links

MeSH TRPV4+protein,+human

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e Membrane transport protein: ion channels

Ca²⁺: Calcium channel	Voltage-dependent calcium channel (L-type/Ca_vα(1.1, 1.2, 1.3, 1.4), N-type, P-type/Ca_vα(2.1), Q-type, R-type, T-type, α₂δ-subunits (1, 2), β-subunits (β1, β2, β3, β4), γ-subunits (γ1, γ2, γ3, γ4) Inositol triphosphate receptor • Ryanodine receptor • Cation channels of sperm • Two-pore channel

Na⁺: Sodium channel	Na_vα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.9, 7A) • Na_vβ (1, 2, 3, 4) • Epithelial sodium channel

K⁺: Potassium channel	Voltage-gated (K_vα (1.1, 1.2, 1.3, 1.4, 1.5, 2.1, 3.1, 3.4, 4.1, 4.2, 4.3, 6.1, 7.1, 7.2, 7.3, 7.4, 7.5, 9.3, 10.1, 11.1/hERG) • K_vβ (1, 2), Shaker gene, KCNE1) Calcium-activated (BK channel: α1, β1, β2, β3, β4; SK channel: SK1, SK2, SK3, SK4) Inward-rectifier K_ir (1.1, 2.1, 2.2, 2.3, 2.4, GIRK, 3.1, 3.2, 3.3, 3.4, 4.1, 4.2, 5.1, 6.1, 6.2, 7.1) Tandem pore domain K2P (1, 2, 3, 4, 6, 9, 15, 17)

Cl^-: Chloride channel	Cystic fibrosis transmembrane conductance regulator

Porin	Aquaporin (1, 2, 3, 4, 5, 7, 8, 9) • Voltage-dependent anion channel (1)

Cations: TRP	TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (Mucolipin-1) • TRPP (1, 2) • TRPV (1, 2, 3, 4, 5, 6)

Other/general	Voltage-gated ion channel • Ligand-gated ion channel • Cyclic nucleotide-gated ion channel (α1, α2, α3, β1, β3, H1, H2, H3, H4) • Stretch-activated ion channel