TRPV3
From Wikipedia, the free encyclopedia
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Transient receptor potential cation channel, subfamily V, member 3
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| Identifiers | ||||||||||||||
| Symbol(s) | TRPV3; VRL3 | |||||||||||||
| External IDs | OMIM: 607066 MGI: 2181407 HomoloGene: 17040 | |||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 162514 | 246788 | ||||||||||||
| Ensembl | ENSG00000167723 | ENSMUSG00000043029 | ||||||||||||
| Uniprot | Q8NET8 | Q32MT8 | ||||||||||||
| Refseq | NM_145068 (mRNA) NP_659505 (protein) |
NM_145099 (mRNA) NP_659567 (protein) |
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| Location | Chr 17: 3.36 - 3.41 Mb | Chr 11: 73.08 - 73.11 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Transient receptor potential cation channel, subfamily V, member 3, also known as TRPV3, is a human gene.
This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member (TRPV1) gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels.[1]
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[edit] Physiology of TRPV3 channel
The TRPV3 gene encodes the TRPV3 channel. This channel is widely expressed in the human body, especially in the skin in keratinocytes, but also in the brain. It functions as a molecular sensor for innocuous warm temperatures.[2] Mice lacking these protein are unable to sense elevated temperatures (>33 °C) but are able to sense cold and noxious heat.[3] In addition to thermosenstation TRPV3 channels seem to play a role in hair growth because mutations in the TRPV3 gene cause hair loss in mice.[4] The role of TRPV3 channels in the brain is unclear.
[edit] Modulation
The TRPV3 channel is directly activated by various natural compounds like carvacrol, thymol and eugenol.[5] Several other monoterpenoids which cause either feeling of warmth or are skin sensitizers can also open the channel.[6]
[edit] See also
[edit] References
- ^ Entrez Gene: TRPV3 transient receptor potential cation channel, subfamily V, member 3.
- ^ Peier AM, Reeve AJ, Andersson DA, et al (2002). "A heat-sensitive TRP channel expressed in keratinocytes". Science (journal) 296 (5575): 2046–9. doi:. PMID 12016205.
- ^ Moqrich A, Hwang SW, Earley TJ, et al (2005). "Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin". Science (journal) 307 (5714): 1468–72. doi:. PMID 15746429.
- ^ Imura K, Yoshioka T, Hikita I, et al (2007). "Influence of TRPV3 mutation on hair growth cycle in mice". Biochem. Biophys. Res. Commun. 363 (3): 479–83. doi:. PMID 17888882.
- ^ Xu H, Delling M, Jun JC, Clapham DE (2006). "Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels". Nat. Neurosci. 9 (5): 628–35. doi:. PMID 16617338.
- ^ Vogt-Eisele AK, Weber K, Sherkheli MA, et al (2007). "Monoterpenoid agonists of TRPV3". Br. J. Pharmacol. 151 (4): 530–40. doi:. PMID 17420775.
[edit] Further reading
- Clapham DE, Julius D, Montell C, Schultz G (2006). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.". Pharmacol. Rev. 57 (4): 427–50. doi:. PMID 16382100.
[edit] External links
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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