TRPM7

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Transient receptor potential cation channel, subfamily M, member 7
PDB rendering based on 1ia9.
Available structures: 1ia9, 1iah, 1iaj
Identifiers
Symbol(s)	TRPM7; CHAK; CHAK1; FLJ20117; FLJ25718; LTRPC7; TRP-PLIK
External IDs	OMIM: 605692 MGI: 1929996 HomoloGene: 9774
Gene ontology Molecular Function: • nucleotide binding • actin binding • protein serine/threonine kinase activity • ion channel activity • calcium channel activity • calcium ion binding • ATP binding • zinc ion binding • kinase activity • transferase activity • myosin binding Cellular Component: • ruffle • plasma membrane • integral to membrane Biological Process: • ion transport • calcium ion transport • calcium-dependent cell-matrix adhesion • actomyosin structure organization and biogenesis • protein amino acid autophosphorylation
Orthologs
	Human	Mouse
Entrez	54822	58800
Ensembl	ENSG00000092439	ENSMUSG00000027365
Uniprot	Q96QT4	Q923J1
Refseq	NM_017672 (mRNA) NP_060142 (protein)	NM_021450 (mRNA) NP_067425 (protein)
Location	Chr 15: 48.64 - 48.77 Mb	Chr 2: 126.48 - 126.57 Mb
Pubmed search	[1]	[2]

Transient receptor potential cation channel, subfamily M, member 7, also known as TRPM7, is a human gene.

TRPCs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.[supplied by OMIM]^[1]

Contents 1 See also 2 References 3 Further reading 4 External links

[edit] See also

• TRPM

[edit] References

[edit] Further reading

[edit] External links

• MeSH TRPM7+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e Membrane transport protein: ion channels Ca2+: Calcium channel Voltage-dependent calcium channel (L-type/Cavα(1.1, 1.2, 1.3, 1.4), N-type, P-type/Cavα(2.1), Q-type, R-type, T-type, α2δ-subunits (1, 2), β-subunits (β1, β2, β3, β4), γ-subunits (γ1, γ2, γ3, γ4) Inositol triphosphate receptor • Ryanodine receptor • Cation channels of sperm • Two-pore channel Na+: Sodium channel Navα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.9, 7A) • Navβ (1, 2, 3, 4) • Epithelial sodium channel K+: Potassium channel Voltage-gated (Kvα (1.1, 1.2, 1.3, 1.4, 1.5, 2.1, 3.1, 3.4, 4.1, 4.2, 4.3, 6.1, 7.1, 7.2, 7.3, 7.4, 7.5, 9.3, 10.1, 11.1/hERG) • Kvβ (1, 2), Shaker gene, KCNE1) Calcium-activated (BK channel: α1, β1, β2, β3, β4; SK channel: SK1, SK2, SK3, SK4) Inward-rectifier Kir (1.1, 2.1, 2.2, 2.3, 2.4, GIRK, 3.1, 3.2, 3.3, 3.4, 4.1, 4.2, 5.1, 6.1, 6.2, 7.1) Tandem pore domain K2P (1, 2, 3, 4, 6, 9, 15, 17) Cl-: Chloride channel Cystic fibrosis transmembrane conductance regulator Porin Aquaporin (1, 2, 3, 4, 5, 7, 8, 9) • Voltage-dependent anion channel (1) Cations: TRP TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (Mucolipin-1) • TRPP (1, 2) • TRPV (1, 2, 3, 4, 5, 6) Other/general Voltage-gated ion channel • Ligand-gated ion channel • Cyclic nucleotide-gated ion channel (α1, α2, α3, β1, β3, H1, H2, H3, H4) • Stretch-activated ion channel